Abstract
The relationships between catalytic activity of cytochrome P450 2A6 (CYP2A6), polymorphism of CYP2A6 gene, gender and levels of body iron stores were analysed in a sample group of 202 apparently healthy Thais, aged 19-47 years. Eleven individuals were found to have high activity of CYP2A6, judged by the relatively large amounts (11.2-14.6 mg) of 7-hydroyxcoumarin (7-OHC) excreted 3 h following administration of 15 mg of coumarin. Ten individuals, however, did not excrete any 7-OHC. Of these 10, four were found to have no CYP2A6 gene (whole gene deletion; CYP2A6*4 allele). The frequency of the CYP2A6 alleles; *1A, *1B and *4 in the whole sample group was 52, 40 and 8% while the frequency of the CYP2A6 gene types; *1A/*1A, *1A/*1B, *1B/*1B, *1A/*4, *1B/*4, *4/*4 was 29, 41, 16, 7, 5 and 2%. Subjects having CYP2A6*1A/*1B gene-type group were found to have higher rates of coumarin 7-hydroxylation compared with those of the CYP2A6*1B/*1B and CYP2A6*1A/*4 gene types. The inter-individual variability in CYP2A6 catalytic activity was therefore attributed in part to the CYP2A6 genetic polymorphism. Variation in CYP2A6 activity in this sample group was not associated with gender but, interestingly, it did show an inverse association with...Continue Reading
References
Oct 1, 1992·Pharmacogenetics·A RautioO Pelkonen
Oct 1, 1992·Carcinogenesis·H YamazakiT Shimada
Mar 27, 1992·Journal of Chromatography·S CholertonJ R Idle
Jan 1, 1991·European Journal of Clinical Pharmacology·H KraulA Hoffmann
Jan 1, 1990·Drug Metabolism Reviews·D EganR D Thornes
Apr 15, 1990·The Biochemical Journal·J S MilesC R Wolf
Jan 1, 1985·British Journal of Clinical Pharmacology·O PelkonenJ T Ahokas
Mar 1, 1994·Mutation Research·M R Haswell-ElkinsD B Elkins
Dec 1, 1994·Environmental Health Perspectives·M BerglundM Vahter
Jan 1, 1995·British Journal of Clinical Pharmacology·E A SotaniemiO Pelkonen
Nov 15, 1994·International Journal of Cancer. Journal International Du Cancer·M R Haswell-ElkinsD B Elkins
Jan 1, 1994·Journal of Cancer Research and Clinical Oncology·O PelkonenJ Hakkola
Feb 1, 1996·Toxicology and Applied Pharmacology·M VahterA Akesson
Jan 1, 1996·Journal of Gastroenterology and Hepatology·J GeorgeG C Farrell
May 1, 1996·Environmental Health Perspectives·H Bartsch, E Hietanen
Oct 1, 1996·Journal of Pharmacokinetics and Biopharmaceutics·S A WrightonB J Ring
Apr 1, 1996·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T ShimadaF P Guengerich
Nov 14, 1997·Toxicology·M PasanenA Rautio
May 20, 1998·Pharmaceutical Research·T Yokoi, T Kamataki
Jul 31, 1998·Pharmacogenetics·K NunoyaT Kamataki
Aug 26, 1998·Drug Metabolism Reviews·C A Mugford, G L Kedderis
Apr 13, 1999·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C Ioannides
Apr 27, 1999·FEBS Letters·M OscarsonM Ingelman-Sundberg
Jun 3, 1999·Biochemical Pharmacology·S KoskelaH Raunio
Jun 8, 1999·Chemico-biological Interactions·K R Iyer, M W Sinz
Jun 22, 1999·Lancet·J R Idle
Jun 26, 1999·Lancet·H ZollerG Weiss
Aug 12, 1999·Biochemical and Biophysical Research Communications·M MiyamotoT Kamataki
Sep 2, 1999·Pharmacogenetics·G F ChenF F Kadlubar
Oct 13, 1999·Mutation Research·T KamatakiK Fujita
Oct 7, 2000·Annals of Epidemiology·C T SemposC L Johnson
Oct 18, 2000·Toxicology and Applied Pharmacology·D B TullyR E Chapin
Dec 29, 2000·Annals of Hematology·N MilmanL Ovesen
Jan 4, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·C M DreslerM L Clapper
Feb 17, 2001·Clinical Pharmacology and Therapeutics·M NakajimaT Yokoi
Feb 24, 2001·Pharmacogenetics·N AriyoshiT Kamataki
Feb 24, 2001·Pharmacogenetics·M A LoriotI Stücker
Mar 10, 2001·Environmental Research·P G Reeves, R L Chaney
Mar 10, 2001·Biochemical and Biophysical Research Communications·N AriyoshiT Kamataki
Jul 4, 2001·Pharmacogenetics·J T KwonT Yokoi
Sep 12, 2001·Biochemical Pharmacology·J R BakerD J Williams
Citations
Nov 4, 2008·European Journal of Clinical Pharmacology·M I VeigaJ P Gil
Dec 17, 2008·European Journal of Clinical Pharmacology·Wiratchanee MahavorasirikulKesara Na-Bangchang
Oct 7, 2009·Environmental Geochemistry and Health·Roongnapa ApinanKesara Na-Bangchang
Mar 26, 2004·Toxicology Letters·Soisungwan SatarugMichael R Moore
Sep 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Edward F DominoKari S Fedewa
Sep 6, 2003·Cancer Letters·Marco Antonio Velasco-VelázquezJuan Mandoki
Nov 8, 2005·Pharmacogenetics and Genomics·Shuwen HuangIan N M Day
Nov 9, 2004·Environmental Health Perspectives·Soisungwan SatarugMichael R Moore
May 7, 2014·Biological Trace Element Research·Byung-Kook LeeYangho Kim
Feb 20, 2004·Human Mutation·Marià PitarqueMagnus Ingelman-Sundberg
Nov 1, 2009·Environmental Toxicology and Pharmacology·Roongnapa ApinanKesara Na-Bangchang
Sep 25, 2004·Toxicology·Soisungwan SatarugMichael R Moore
Dec 28, 2005·Biochemical and Biophysical Research Communications·Jue WangMagnus Ingelman-Sundberg
Jan 16, 2007·Drug Metabolism and Pharmacokinetics·Sompop PeamkrasatamKrongtong Yoovathaworn
Dec 25, 2004·Drug Metabolism and Pharmacokinetics·Kazuma KiyotaniTetsuya Kamataki
Nov 15, 2011·Environmental Research·Byung-Kook Lee, Yangho Kim
Dec 17, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Kyoung Sook JeongYangho Kim
Jun 25, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Na GaoHailing Qiao
Mar 1, 2005·Pharmacological Reviews·Janne HukkanenNeal L Benowitz
Jan 27, 2005·The Journal of Pharmacology and Experimental Therapeutics·Marià PitarqueMagnus Ingelman-Sundberg
Dec 18, 2019·International Journal of Toxicology·ChingYi Jennifer HsiehMartha S Sandy
Nov 6, 2007·Molecular Pharmacology·Tania OnicaGordon M Kirby
Jun 17, 2005·Carcinogenesis·Masafumi MiyazakiTetsuya Kamataki
Oct 30, 2003·Pharmacogenetics·Kazuma KiyotaniTetsuya Kamataki
Jul 25, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Eriko HigashiMiki Nakajima
Jun 28, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Miyuki KimuraTetsuya Kamataki
Dec 29, 2019·The Journal of Pharmacology and Experimental Therapeutics·Yan FangHai-Ling Qiao
Nov 3, 2020·The Journal of Toxicological Sciences·Tomonori MiuraHiroshi Yamazaki
Aug 3, 2021·The Journal of Toxicological Sciences·Norie Murayama, Hiroshi Yamazaki