PMID: 9541192Apr 16, 1998Paper

Variation in endometrial thickening in women with amenorrhea on tamoxifen

Breast Cancer Research and Treatment
J ChangMitch Dowsett

Abstract

Tamoxifen is reported to increase the risk of endometrial cancers mostly in postmenopausal women. In the Royal Marsden chemoprevention programme, we noted that premenopausal women at the start of tamoxifen/placebo who developed amenorrhea may be at special risk of endometrial cancer. The aim of this report was to investigate recently amenorrheic women by measuring plasma estradiol (E2), follicular stimulating hormone (FSH), and endometrial thickness (ET) by transvaginal ultrasound (TVUS). ET readings and E2 levels were available in the same proportion of women on tamoxifen or placebo. Women on placebo developed amenorrhea with upper limit of E2 readings of 450 pmol/L. In both postmenopausal women and recently amenorrheic women with low E2 (< or = 450 pmol/L), tamoxifen significantly increased endometrial thickening (p < 0.0001 and < 0.005 respectively). Conversely, tamoxifen did not result in endometrial thickening in women with high E2 (> 450 pmol/L), with a trend to lower ET readings (p = 0.07). Finally, all five women who developed endometrial cancer were premenopausal at the start of tamoxifen/placebo. Two of these five women were asymptomatic with increased ET readings (17 mm and 17 mm) and low E2 levels (32 and 51 pmol/L)...Continue Reading

References

Oct 1, 1991·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·X De MuylderE De Muylder
Jul 17, 1991·Journal of the National Cancer Institute·M AnderssonH T Mouridsen
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T J PowlesJ A McKinna
Feb 1, 1990·British Journal of Obstetrics and Gynaecology·S S Cross, S M Ismail
May 1, 1990·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P NevenE De Muylder
Sep 20, 1995·Journal of the National Cancer Institute·T J Powles, T Hickish
Feb 1, 1995·Obstetrics and Gynecology·D GradyD Petitti
Feb 19, 1994·Lancet·F E van LeeuwenF W Diepenhorst
Sep 1, 1994·Journal of Clinical Pathology·S M Ismail
Jan 1, 1994·Breast Cancer Research and Treatment·T J PowlesM Baum
Aug 21, 1993·Lancet·P Neven
Jun 1, 1993·British Journal of Obstetrics and Gynaecology·I CohenY Beyth
Jan 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F J CummingsJ M Bennett
Aug 21, 1996·Journal of the National Cancer Institute·N PotischmanJ R Lurain

❮ Previous
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Citations

May 5, 2001·Obstetrics and Gynecology·M J MouritsA G Van der Zee
Sep 21, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D AndíaJ M Usandizaga
Aug 1, 2000·Maturitas·J Marsden
Oct 12, 2000·The New England Journal of Medicine·H J Burstein, E P Winer
Jun 18, 2002·The Lancet Oncology·Jo Marsden
Apr 1, 2014·Gynecologic Oncology·Daniel M Lubián LópezRafael Comino Delgado
Oct 19, 2000·Cancer Investigation·R Y Lam, R T Chlebowski
Jan 27, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·P Neven, H Vernaeve
Feb 11, 2011·Mayo Clinic Proceedings·Jamie N Bakkum-GamezSandhya Pruthi
Apr 25, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Susanne C J P GielenLeen J Blok
May 28, 2009·Journal of Gynecologic Oncology·Ho Sung KimYong Beom Kim
Jul 27, 1999·Annals of Internal Medicine·E J Suh-Burgmann, A Goodman
May 14, 2010·Menopause : the Journal of the North American Menopause Society·Daniel María Lubian LópezRafael Comino Delgado
Sep 13, 2012·Menopause : the Journal of the North American Menopause Society·Daniel María Lubián LópezRafael Comino Delgado
Jul 17, 2007·Human Reproduction Update·Frances McFarland Horne, Diana L Blithe
Sep 24, 2015·Cancer Prevention Research·Carol J FabianBrandy M Heckman-Stoddard

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