Variation in estimated viral suppression associated with the definition of viral suppression used.

AIDS
Catherine R LeskoBryan Lau

Abstract

The proportion of people living with HIV with suppressed viral load is a key indicator of the HIV care continuum. We explored how this proportion varied depending on how it was calculated. Observational cohort study. We calculated the proportion of the Johns Hopkins HIV Clinical Cohort who were virally suppressed each year, 2010-2018, based on different denominators; thresholds for suppression (≤20, ≤50, ≤200, or ≤400 copies/ml); and strategies for summarizing multiple viral load measurements (we classified persons as suppressed if they had any lab, ≥50% of labs, last lab, or all labs below the threshold). We also calculated 5-year risk of all-cause mortality associated with each classification of viral suppression. Three thousand eleven persons contributed 60 858 viral load values to this analysis. Proportion classified as virally suppressed ranged from 51.8 to 92.5%, depending on the definition used and persons included in the calculation. Requiring more labs below the threshold; using a lower threshold; and assuming persons lost to follow-up were not suppressed (stricter definitions) resulted in a lower proportion estimated to be suppressed. Suppression by stricter definitions were associated with better 5-year survival. The...Continue Reading

References

Aug 24, 2000·Epidemiology·J M RobinsB Brumback
Oct 22, 2003·Epidemiology·Tosiya Sato, Yutaka Matsuyama
Jul 20, 2011·The New England Journal of Medicine·Myron S CohenUNKNOWN HPTN 052 Study Team
Jan 10, 2012·Current Opinion in HIV and AIDS·Evan WoodJulio S G Montaner
Apr 7, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Franco MaggioloSebastiano Leone
Mar 30, 2013·The Lancet Infectious Diseases·William C MillerMyron S Cohen
May 17, 2013·Bulletin of the World Health Organization·James H McMahonMichael R Jordan
Aug 16, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Claudie LapriseHelen Trottier
Feb 18, 2015·AIDS·UNKNOWN Antiretroviral Therapy Cohort Collaboration (ART-CC)Philippe Morlat
Jul 21, 2015·The New England Journal of Medicine·UNKNOWN INSIGHT START Study GroupJames D Neaton
Nov 15, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonathan ColasantiWendy S Armstrong
Apr 23, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Gary MarksEdward R Cachay
Jul 1, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicole CrepazH Irene Hall
Aug 9, 2017·Annals of Internal Medicine·Nicole CrepazH Irene Hall
Mar 22, 2019·MMWR. Morbidity and Mortality Weekly Report·Zihao LiH Irene Hall

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