PMID: 7512627Jan 1, 1994Paper

Variation in IH, IIR, and ILEAK between acutely isolated adult rat dorsal root ganglion neurons of different size

Journal of Neurophysiology
R S ScroggsA P Fox

Abstract

1. The distribution of IH, IIR, and ILEAK was studied in different diameter rat dorsal root ganglion (DRG) neuron cell bodies (neurons). DRG neurons were studied in three diameter ranges: small (19-27 microns), medium (33-37 microns), and large (44-54 microns). IH was defined as a slowly activating inward current evoked by hyperpolarizing voltage steps from a holding potential (HP) of -60 mV, and blocked by 1 mM Cs2+ but not 1 mM Ba2+. Inward rectifier current (IIR) was defined as a rapidly activating current evoked by hyperpolarizations from HP -60 mV, which rectified inwardly around the reversal potential for potassium (EK), and was completely blocked by 100 microM Ba2+. ILEAK was defined as an outward resting current at HP -60 mV, which did not rectify and was blocked by 100 microM Ba2+ but not by 2 mM Cs+. 2. IH was observed in 23 of 23 large, 11 of 12 medium, and in 9 of 20 small diameter DRG neurons tested. Peak IH normalized to membrane surface area was significantly greater in large than in medium or small diameter DRG neurons expressing IH. All neurons exhibiting IH under voltage clamp conditions had short duration action potentials and exhibited time-dependent rectification under current clamp conditions, properties s...Continue Reading

Citations

Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·D B Reichling, J D Levine
Dec 1, 1998·British Journal of Pharmacology·A RaesP P van Bogaert
Feb 24, 2001·The European Journal of Neuroscience·F VianaC Belmonte
Sep 30, 2004·Science's STKE : Signal Transduction Knowledge Environment·Ru-Rong Ji, Gary Strichartz
Oct 17, 2006·The European Journal of Neuroscience·Junichi KitagawaKoichi Iwata
Oct 22, 2008·The Journal of Physiology·Aliakmal MominPeter A McNaughton
Sep 8, 2012·Journal of Neurophysiology·Patricio OrioFélix Viana
Jan 13, 2015·International Journal of Molecular Sciences·Stefan HerrmannAndreas Ludwig
Sep 14, 1999·Journal of Neurophysiology·E C BurgardM F Jarvis
Sep 24, 1999·Pain·David B Reichling, Jon D Levine
Dec 19, 2006·Pain Practice : the Official Journal of World Institute of Pain·Sean M BrownSandra R Chaplan
Feb 21, 2008·The Journal of Physiological Sciences : JPS·Yoshiki MatsudaShinichi Kogure
Jul 9, 2009·Physiological Reviews·Martin BielXiangang Zong
Jun 8, 2012·American Journal of Physiology. Cell Physiology·Elke BocksteinsDirk J Snyders
Mar 1, 1997·Journal of Neurophysiology·Z L Mo, R L Davis
Feb 13, 2001·Journal of Neurophysiology·F A Abdulla, P A Smith
Jun 11, 2005·The Journal of Pharmacology and Experimental Therapeutics·Refik KanjhanMark C Bellingham
Feb 12, 2002·Nature Neuroscience·Félix VianaCarlos Belmonte
Mar 30, 2007·Journal of Neurophysiology·Dmitry V VasilyevJohn Dunlop

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