Variation in incidence of pediatric Crohn's disease in relation to latitude and ambient ultraviolet radiation: a systematic review and analysis

Inflammatory Bowel Diseases
Elizabeth A HolmesRobyn Lucas

Abstract

Pediatric Crohn's disease (CD) is a lifelong, debilitating, and costly disease. In previous studies, CD incidence increased with higher geographic latitude in the Northern Hemisphere. This may indicate a role for lower vitamin D status as a risk factor for CD. Analysis of worldwide incidence of pediatric CD has not been previously reported. We undertook a systematic review of population-based studies reporting incidence of pediatric CD and published between 2003 and 2013. Included studies had well-defined diagnostic criteria for CD, evidence of high case ascertainment, reported incidence according to age group, and provided a specific location. Average daily ambient ultraviolet radiation (UVR) for each location was derived from satellite data. Negative binomial regression was used to assess the association between pediatric CD incidence and latitude and ambient UVR, adjusting for the study year. Twenty-eight articles provided 39 incidence data points. Incidence of pediatric CD increased with higher latitude, and in association with a greater number of months where the average daily UVR was lower than a previously published threshold of 1.488 kJ/m. Incidence of pediatric CD increased over calendar time. After applying rigorous q...Continue Reading

References

Apr 13, 2004·Journal of Pediatric Gastroenterology and Nutrition·H J van der Zaag-LoonenH H F Derkx
Apr 13, 2004·Journal of Pediatric Gastroenterology and Nutrition·Antonín KolekMichal Grepl
Dec 25, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mathieu BoniolUNKNOWN EUROCARE Working Group
Mar 23, 2006·Archives of Disease in Childhood·M AhmedH R Jenkins
Apr 26, 2006·Scandinavian Journal of Gastroenterology·Brankica Mijandrusić SincićDavor Stimac
Jun 13, 2006·Progress in Biophysics and Molecular Biology·Ann R Webb
Aug 19, 2006·Inflammatory Bowel Diseases·Pieta TurunenMerja Ashorn
Aug 22, 2006·American Journal of Epidemiology·Chris GreenCharles N Bernstein
Oct 3, 2006·Inflammatory Bowel Diseases·Richard B GearryMurray L Barclay
Apr 21, 2007·Annals of Neurology·Alberto Ascherio, Kassandra L Munger
Oct 2, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael D KappelmanJonathan A Finkelstein
Sep 17, 2008·European Journal of Gastroenterology & Hepatology·Claudia OttAntje Timmer
Oct 16, 2008·Gastroenterology·Michael D KappelmanJonathan A Finkelstein
Apr 16, 2009·Journal of Pediatric Gastroenterology and Nutrition·Rok OrelPetar Mamula
May 13, 2009·Journal of Pediatric Surgery·Tanya Grieci, Andreana Bütter
Sep 24, 2009·Inflammatory Bowel Diseases·Christophe DeclercqJean-Frédéric Colombel
Nov 26, 2009·Journal of Pediatric Gastroenterology and Nutrition·Hoda M MalatyGeorge D Ferry
Jan 16, 2010·Journal of Gastroenterology and Hepatology·Richard B GearryMurray L Barclay
Jun 22, 2010·Inflammatory Bowel Diseases·Eric I BenchimolAnne M Griffiths
Jun 1, 2008·Journal of Crohn's & Colitis·Christian JakobsenAnders Paerregaard
Jan 12, 2011·Digestive Diseases and Sciences·Alon D LevinAndrew S Day
Feb 22, 2011·Alimentary Pharmacology & Therapeutics·V NerichF Carbonnel
Jun 21, 2011·Inflammatory Bowel Diseases·Paul HendersonDavid C Wilson
Jul 12, 2011·Inflammatory Bowel Diseases·Pieta LehtinenAnssi Auvinen
Aug 20, 2011·Nature Reviews. Immunology·Prue H HartJohn J Finlay-Jones
Sep 14, 2011·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Wafa'a A Al-QabandiJohnPatrick Madda
Feb 14, 2012·Journal of Crohn's & Colitis·Treasa Nic SuibhneMaria O'Sullivan
May 3, 2012·Archives of Disease in Childhood·B HopeB Bourke
Nov 13, 2012·Journal of Crohn's & Colitis·Airi JussilaMartti A Färkkilä
Feb 14, 2013·Journal of Crohn's & Colitis·Søren Peter JørgensenJens Frederik Dahlerup
Mar 6, 2013·Journal of Pediatric Gastroenterology and Nutrition·Petter MalmborgHans Hildebrand

❮ Previous
Next ❯

Citations

Aug 27, 2015·Journal of Pediatric Gastroenterology and Nutrition·Tatiana Y FofanovaRichard Kellermayer
Jul 28, 2016·Current Gastroenterology Reports·Sara Iqbal, Eamonn M M Quigley
Apr 1, 2017·Scandinavian Journal of Gastroenterology·Francisca JaimeArturo Borzutzky
Feb 28, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·R M LucasR E Neale
Jul 29, 2016·World Journal of Gastroenterology : WJG·Ayokunle T AbegundeTauseef Ali
Jan 11, 2017·Mediators of Inflammation·Ekaterina VasilyevaAlbert Rizvanov
May 21, 2019·Journal of Pediatric Gastroenterology and Nutrition·Elizabeth Ann HolmesUNKNOWN PAID consortium
Jun 27, 2019·Nutrients·Fernando Castro, Heitor S P de Souza
Dec 11, 2020·Journal of Clinical Medicine·Aleksandra Glapa-NowakJarosław Walkowiak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.