Variation in Inflammatory Response during Pneumococcal Infection Is Influenced by Host-Pathogen Interactions but Associated with Animal Survival

Infection and Immunity
Magda S JonczykPeter W Andrew

Abstract

Inflammation is a crucial part of innate immune responses but, if imbalanced, can lead to serious clinical conditions or even death. Cytokines regulate inflammation, and studies report their impact on clinical outcome. However, host and pathogen genetic backgrounds influence cytokine production, making it difficult to evaluate which inflammatory profiles (if any) relate to improved prognosis.Streptococcus pneumonia is a common human pathogen associated with asymptomatic nasopharyngeal carriage. Infrequently, it can lead to a wide range of diseases with high morbidity and mortality rates. Studies show that both pneumococcal serotype and host genetic background affect the development of disease and contribute to variation in inflammatory responses. In this study, we investigated the impact of the host and pneumococcal genetic backgrounds on pulmonary cytokine responses and their relationship to animal survival. Two inbred mouse strains, BALB/c and CBA/Ca, were infected with 10 pneumococcal strains, and the concentrations of six pulmonary cytokines were measured at 6 h and 24 h postinfection. Collected data were analyzed by principal-component analysis to identify whether there is any pattern in the observed cytokine variation. Ou...Continue Reading

References

Jan 1, 1997·Infection and Immunity·K TakashimaK Yamaguchi
Jan 1, 1997·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·R T StraitR W Wilmott
Jul 10, 2001·The Journal of Infectious Diseases·F DallaireM G Bergeron
Jan 5, 2002·The Journal of Infectious Diseases·Anita W RijneveldTom Van Der Poll
Feb 21, 2002·Infection and Immunity·Alison R KerrTim J Mitchell
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Koenraad F van der SluijsTom van der Poll
Jul 2, 2004·BMC Infectious Diseases·Pernille MartensThomas Benfield
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Daniel M MusherAnna Wanahita
Nov 3, 2009·Lancet·Tom van der Poll, Steven M Opal
Feb 9, 2011·Current Opinion in Infectious Diseases·Grant Waterer, Jordi Rello
Jul 19, 2011·The Journal of Infection·Vicente F Corrales-Medina, Daniel M Musher
May 9, 2012·PLoS Pathogens·Daniel R NeillPeter W Andrew
Apr 11, 2013·Current Opinion in Infectious Diseases·Joshua Vernatter, Liise-anne Pirofski
Jul 16, 2013·PLoS Pathogens·Anna K CoussensAdrian R Martineau

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Citations

Feb 13, 2021·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Qianglai TanHua Wei

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
PCR
PCA

Software Mentioned

Solo
GenomeStudio
SPSS
PASW Statistics
GraphPad Prism
dCHIP
ArrayTrack
DAVID

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