Variation in lung cancer risk by smoky coal subtype in Xuanwei, China.

International Journal of Cancer. Journal International Du Cancer
Qing LanRobert S Chapman

Abstract

Lung cancer rates in Xuanwei County have been among the highest in China for both males and females and have been causally associated with exposure to indoor smoky (bituminous) coal emissions that contain very high levels of polycyclic aromatic hydrocarbons. There are numerous coal mines across the County. Although lung cancer risk is strongly associated with the use of smoky coal as a whole, variation in risk by smoky coal subtype has not been characterized as yet. We conducted a population-based case-control study of 498 lung cancer cases and 498 controls, individually matched to case subjects on age (+/-2 years) and sex to examine risk by coal subtype. Odds ratios (ORs) and 95% confidence intervals (CIs) for coal subtype were calculated by conditional logistic regression, adjusting for potential confounders. Overall, smoky coal use was positively and statistically significantly associated with lung cancer risk, when compared with the use of smokeless coal or wood (OR = 7.7, 95% CI = 4.5-13.3). Furthermore, there was a marked heterogeneity in risk estimates for specific subtypes of smoky coal (test for heterogeneity: p = 5.17 x 10(-10)). Estimates were highest for coal of the Laibin (OR = 24.8, 95% CI = 12.4-49.6) and Longtan...Continue Reading

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Citations

Jul 31, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·H Dean HosgoodIIIQing Lan
Sep 1, 2012·BMJ : British Medical Journal·Francesco Barone-AdesiQing Lan
Sep 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jonathan M SametCharles M Rudin
Aug 1, 2012·Environmental Health Perspectives·Britt C ReidLinda S Birnbaum
Sep 1, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Gongbo ChenGonghuan Yang
Oct 29, 2011·The Medical Clinics of North America·Laurie L CarrJeffrey A Kern
Mar 17, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·H Dean HosgoodQing Lan
Aug 26, 2015·Frontiers of Medicine·Hualiang LinLinwei Tian
Jan 27, 2009·Environmental and Molecular Mutagenesis·Min ShenQing Lan
Oct 12, 2011·American Journal of Industrial Medicine·H Dean HosgoodQing Lan
Jun 5, 2014·Environmental and Molecular Mutagenesis·H Dean HosgoodQing Lan
Feb 11, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Christopher KimQing Lan
May 11, 2016·International Journal of Environmental Research and Public Health·Hongyan RenGonghuan Yang
Dec 5, 2018·International Journal of Cancer. Journal International Du Cancer·Jason Y Y WongQing Lan
Sep 16, 2019·Cancer Causes & Control : CCC·Madelyn KlugmanH Dean Hosgood
Jan 9, 2020·Annual Review of Public Health·Michael HendryxJuhua Luo
Aug 29, 2020·Environmental Science and Pollution Research International·Zailin ChenQiulian Yu
Jan 14, 2017·Thoracic Cancer·Xiao WangYanliang Zhang
Nov 16, 2018·International Journal of Oncology·Long ChenYunchao Huang
Feb 18, 2020·Atmosphere·H Dean HosgoodQing Lan
May 16, 2019·Journal of Toxicology and Environmental Health. Part a·Jason Y Y WongNathaniel Rothman
Feb 3, 2021·Journal of Cellular and Molecular Medicine·Guangjian LiYunchao Huang
Nov 6, 2020·Cancer Management and Research·Yuhui MaYongchun Zhou
Dec 1, 2009·Environmental Science & Technology·David J LargeYiping Zhou

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