Variation in lung function is associated with worse clinical outcomes in cystic fibrosis

Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
João Paulo Heinzmann-FilhoMárcio Vinícius Fagundes Donadio

Abstract

To determine whether the variation in lung function over one year is associated with worse clinical outcomes, as well as with a decline in lung function in the following years, in patients with cystic fibrosis (CF). This was a retrospective study involving CF patients (4-19 years of age), evaluated over a three-year period. We evaluated demographic characteristics, chronic Pseudomonas aeruginosa infection, antibiotic use, hospitalization, six-minute walk distance (6MWD), and lung function. The inclusion criterion was having undergone pulmonary function testing at least three times in the first year and at least once in each of the next two years. We evaluated 35 CF patients. The variation in FEV1 in the first year (ΔFEV1) was greater among those who, in the third year, showed reduced FEV1, had a below-average 6MWD, or were hospitalized than among those with normal FEV1, normal 6MWD, or no hospital admissions, in that same year (p < 0.05), although no such difference was found for antibiotic use in the third year. Subjects showing a ΔFEV1 ≥ 10% also showed a greater decline in FEV1 over the two subsequent years (p = 0.04). The ΔFEV1 also showed an inverse correlation with absolute FEV1 in the third year (r = -0.340, p = 0.04) an...Continue Reading

References

Jan 15, 1998·The Journal of Pediatrics·M CoreyM Knowles
Apr 26, 2001·Journal of the American Dietetic Association·L T BekerR J Fink
Jul 2, 2002·American Journal of Respiratory and Critical Care Medicine·UNKNOWN ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories
Nov 8, 2003·American Journal of Respiratory and Critical Care Medicine·Paul L EnrightDuane L Sherrill
Oct 29, 2004·Current Opinion in Pulmonary Medicine·Carlos E Milla
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Jan 28, 2006·American Journal of Respiratory and Critical Care Medicine·David M ManninoKourtney J Davis
Jul 28, 2006·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Kevin W SouthernUNKNOWN ECFS CF Neonatal Screening Working Group
Dec 22, 2006·The European Respiratory Journal·J A DodgeJ Wilsher
Mar 27, 2007·The Journal of Pediatrics·Ralf GeigerJoerg I Stein
Jul 24, 2007·The Journal of Pediatrics·Michael W KonstanUNKNOWN Scientific Advisory Group and the Investigators and Coordinators of the Epidemiologic Study of Cystic Fibrosis
Oct 2, 2007·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Bruna ZieglerPaulo de Tarso Roth Dalcin
Oct 11, 2008·Pediatric Pulmonology·Don B SandersGregory J Redding
Oct 14, 2008·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Ingrid DuguépérouxDominique Hubert
Nov 11, 2008·Pediatric Pulmonology·Oscar H MayerJulian Allen
Nov 26, 2008·Respiratory Medicine·Anna AmadoriVirginia De Rose
Oct 6, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A M IwamaV Z Dourado
Nov 17, 2009·Pediatric Pulmonology·Camila Varella PriesnitzMárcio Vinícius Fagundes Donadio
May 18, 2010·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Theodore G LiouJeffrey S Wagener
Jul 22, 2010·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·M W KonstanD R VanDevanter
Aug 3, 2011·Clinics·Fabíola StollarJoaquim C Rodrigues
Dec 3, 2011·The European Respiratory Journal·Valerie WatersFelix Ratjen
Dec 23, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Fabíola StollarFabíola Villac Adde
May 9, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Michael W KonstanWayne J Morgan
Jun 30, 2012·The European Respiratory Journal·Philip H QuanjerUNKNOWN ERS Global Lung Function Initiative

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Citations

Jan 15, 2017·The Journal of Pediatrics·Márcio V F DonadioPaulo J C Marostica
Mar 21, 2019·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Camila Menna Barros RodriguesJoão Paulo Heinzmann-Filho

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