Variation in neuropathogenicity in sheep fetuses transplacentally infected with non-cytopathogenic and cytopathogenic biotypes of bovine-virus diarrhoea virus

Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B
M Hewicker-TrautweinB Liess

Abstract

Pregnant Merino ewes were inoculated intravenously between days 63 and 65 of gestation with a non-cytopathogenic (ncp) bovine-virus diarrhoea-virus (BVDV) isolate (experiment A). The histomorphological findings and the distribution of viral antigen, as revealed by immunohistochemistry in brains of fetuses from experiment A, were compared with those seen in fetal brains from a previous study (experiment B), in which pregnant ewes had been intravenously infected between days 65 and 68 of gestation with the cytopathogenic (cp) BVDV strain Indiana. The two viruses showed remarkable variations concerning their pathogenicity for the developing fetal brain. The cp BVDV had a much higher neuropathogenic potential than the ncp BVDV and induced severe intracranial malformations in most fetuses. In experiment A, exclusively relatively mild leucoencephalomalacic lesions occurred. Between fetuses of the two experiments, significant differences concerning the distribution of viral antigen and the inflammatory response were found. In the majority of fetal brains from experiment B examined at days 10, 14 and 21 post inoculation (p.i.), antigen-containing differentiated brain cells (neurons, astrocytes, oligodendrocytes) and undifferentiated ce...Continue Reading

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Citations

Oct 12, 2002·American Journal of Veterinary Research·Martha J HardingRuben O Donis
Apr 9, 2014·Veterinary Research·Thomas PasslerPaul H Walz
Mar 18, 2006·Developmental Medicine and Child Neurology·Olaf DammannMarion Hewicker-Trautwein
Apr 6, 2004·The Veterinary Clinics of North America. Food Animal Practice·Steven R Bolin, Daniel L Grooms
Nov 4, 2009·Animal Health Research Reviews·Thomas Passler, Paul H Walz
Mar 16, 2004·Veterinary Pathology·U Blas-MachadoS L Caseltine

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