Variation in osteoarthritis biomarkers from activity not food consumption.

Clinica Chimica Acta; International Journal of Clinical Chemistry
Craig D GordonVirginia B Kraus

Abstract

To optimize sampling and to understand sources of variation in biomarkers for osteoarthritis (OA), we evaluated variation due to activity and food consumption. Twenty participants, with radiographic knee OA, provided serial serum and urine samples at 4 time points: before arising in the morning; after 1 h of light activity; 1 h after eating breakfast; and in the evening. Five serum (s) and 2 urinary (u) analytes were measured: hyaluronan (sHA); cartilage oligomeric matrix protein (sCOMP); keratan sulfate (sKS-5D4); transforming growth factor beta (sTGF-ss1); and collagen II-related epitopes (sCPII, uCTXII, and uC2C). Activity was monitored by an accelerometer. All serum biomarkers increased and one of the urinary biomarkers decreased after 1 h of non-exertional activity. Food consumption following activity was associated with a return of biomarker concentrations to baseline levels. Accelerometers proved to be a novel way to monitor protocol compliance and demonstrated a positive association between the mean level of activity and sCOMP concentration. Urinary CTXII varied the least but demonstrated both true circadian variation (peak in the morning and nadir in the evening) and the most robust correlation with radiographic knee O...Continue Reading

References

Dec 5, 1998·European Journal of Applied Physiology and Occupational Physiology·A RösslerH G Hinghofer-Szalkay
Oct 22, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Kenji YamazakiChiaki Hamanishi
Oct 30, 2003·Annals of the Rheumatic Diseases·F A Wollheim
Sep 13, 2005·Osteoarthritis and Cartilage·Lisa G CriscioneVirginia B Kraus
Apr 7, 2007·Medicine and Science in Sports and Exercise·Ann V RowlandsRoger G Eston

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Citations

Aug 1, 2012·Metabolomics : Official Journal of the Metabolomic Society·Dana K ThompsonVirginia B Kraus
Jun 21, 2011·Lancet·Johannes W J BijlsmaFloris P J G Lafeber
Mar 13, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Agnieszka Jura-PółtorakKrystyna Olczyk
Apr 25, 2008·Osteoarthritis and Cartilage·D J QuintanaV B Kraus
Mar 15, 2011·Osteoarthritis and Cartilage·V B KrausUNKNOWN OARSI FDA Osteoarthritis Biomarkers Working Group
Nov 22, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Adam P GoodeJoanne M Jordan
Apr 29, 2020·Cartilage·Ashley J HanVirginia B Kraus

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