Abstract
A comparative study was carried out on the methanolic extracts from six Achillea species and the examined polyphenols from these plants on the formation of advanced glycation end-products (AGE) in vitro. A. pachycephala which was richer in flavonoids (15 mg quercetin/g W) and phenolics (111.10 mg tannic acid/g DW) with substantial antioxidant activity (IC50 = 365.5 μg/ml) presented strong anti-AGE properties. Chlorogenic acid, luteolin, quercetin and caffeic acid were identified as the major polyphenols in the extracts by HPLC. In general, polyphenolic content follows the order of A. pachycephalla > A. nobilis > A. filipendulina > A. santolina > A. aucheri > A. millefolium. Most extracts exhibited marked anti-AGE ability in the bovine serum albumin (BSA)/methylglyoxal (MG) system, though A. pachycephala showed the highest potential. The formation of AGEs was assessed by monitoring the production of fluorescent products and circular dichroism (CD) spectroscopy. Diminution in free radical production (assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays) is discussed as potential mechanism for delay or reduced AGE. The results demonstrate the antiglycative, antioxidant and antimicrobial potential of Achillea species which can ...Continue Reading
References
Oct 1, 1969·Biochemistry·C G Rosen, G Weber
Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Oct 26, 2001·The Journal of Biological Chemistry·D L PriceJ W Baynes
Aug 12, 2003·The Journal of Biological Chemistry·Barend BoumaMartijn F B G Gebbink
Oct 7, 2004·Critical Reviews in Food Science and Nutrition·Dae-Ok Kim, Chang Yong Lee
Mar 5, 2005·Analytical Biochemistry·Annett SchmittJovana Gasic-Milencovic
Mar 6, 2007·Journal of Ethnopharmacology·Razieh YazdanparastShirin Jamshidi
May 5, 2009·Fitoterapia·A GugliucciMarina F Ferreira Souza
Dec 17, 2009·Biochimica Et Biophysica Acta·Philippe RondeauValeria Militello
Mar 2, 2010·BMC Complementary and Alternative Medicine·Rula M Darwish, Talal A Aburjai
Jun 1, 2011·Journal of Primary Health Care·Phil Rasmussen
Feb 23, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui-Min HanLeif H Skibsted
Jul 19, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thiele Faccim de BrumMargareth Linde Athayde
Oct 17, 2015·Food Chemistry·Wissal KchaouSouhail Besbes
Jan 20, 2016·Journal of the Science of Food and Agriculture·Estefania GenskowskyManuel Viuda-Martos
Jul 28, 2016·Chemistry & Biodiversity·Dara DastanHossein Maroofi
Jul 28, 2016·Food Chemistry·Maryam SalamiMohammad Hossein Ehtemam
Sep 10, 2016·Pharmaceutical Biology·Rashmi S TupeShamim A Shaikh
Nov 20, 2016·Food Chemistry·Behnaz TohidiAhmad Arzani
Nov 25, 2016·Meat Science·Dhekra MhallaMohamed Trigui
Dec 26, 2016·Fitoterapia·Yasmin Bains, Alejandro Gugliucci
Feb 22, 2017·Phytotherapy Research : PTR·Mack MoyoJohannes Van Staden
Citations
Dec 20, 2018·Chemistry & Biodiversity·Ji-Rui WangGang Ding
Jan 31, 2020·Chemistry & Biodiversity·Ismail YenerAbdulselam Ertas
Apr 10, 2019·Polymers·Ludwig Erik AguilarCheol Sang Kim
Jul 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarzyna Gaweł-BębenWirginia Kukula-Koch
Oct 28, 2019·Chemistry & Biodiversity·Muhammed Akif Açıkgöz
Jul 5, 2019·Plant Physiology and Biochemistry : PPB·Ehsan FathiAsad Maroufi
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcelina Strzępek-GomółkaWirginia Kukula-Koch
Mar 5, 2021·Scientific Reports·Danial SarfarazGhodratollah Saeidi
Mar 16, 2019·Phytochemistry·Shima GharibiAdam Matkowski
Apr 10, 2021·Oxidative Medicine and Cellular Longevity·Marcelina Strzępek-GomółkaWirginia Kukula-Koch