Variation in Polyphenolic Profiles, Antioxidant and Antimicrobial Activity of Different Achillea Species as Natural Sources of Antiglycative Compounds

Chemistry & Biodiversity
Mahvash AfshariMehran Miroliaei

Abstract

A comparative study was carried out on the methanolic extracts from six Achillea species and the examined polyphenols from these plants on the formation of advanced glycation end-products (AGE) in vitro. A. pachycephala which was richer in flavonoids (15 mg quercetin/g W) and phenolics (111.10 mg tannic acid/g DW) with substantial antioxidant activity (IC50  = 365.5 μg/ml) presented strong anti-AGE properties. Chlorogenic acid, luteolin, quercetin and caffeic acid were identified as the major polyphenols in the extracts by HPLC. In general, polyphenolic content follows the order of A. pachycephalla > A. nobilis > A. filipendulina > A. santolina > A. aucheri > A. millefolium. Most extracts exhibited marked anti-AGE ability in the bovine serum albumin (BSA)/methylglyoxal (MG) system, though A. pachycephala showed the highest potential. The formation of AGEs was assessed by monitoring the production of fluorescent products and circular dichroism (CD) spectroscopy. Diminution in free radical production (assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays) is discussed as potential mechanism for delay or reduced AGE. The results demonstrate the antiglycative, antioxidant and antimicrobial potential of Achillea species which can ...Continue Reading

References

Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Oct 26, 2001·The Journal of Biological Chemistry·D L PriceJ W Baynes
Aug 12, 2003·The Journal of Biological Chemistry·Barend BoumaMartijn F B G Gebbink
Mar 6, 2007·Journal of Ethnopharmacology·Razieh YazdanparastShirin Jamshidi
Dec 17, 2009·Biochimica Et Biophysica Acta·Philippe RondeauValeria Militello
Mar 2, 2010·BMC Complementary and Alternative Medicine·Rula M Darwish, Talal A Aburjai
Feb 23, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui-Min HanLeif H Skibsted
Jul 19, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Thiele Faccim de BrumMargareth Linde Athayde

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Citations

Jul 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Katarzyna Gaweł-BębenWirginia Kukula-Koch
Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcelina Strzępek-GomółkaWirginia Kukula-Koch
Mar 5, 2021·Scientific Reports·Danial SarfarazGhodratollah Saeidi
Apr 10, 2021·Oxidative Medicine and Cellular Longevity·Marcelina Strzępek-GomółkaWirginia Kukula-Koch

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