Variation in prostate cancer treatment associated with population density of the county of residence

Prostate Cancer and Prostatic Diseases
C CaryM R Cooperberg

Abstract

We sought to assess variation in the primary treatment of prostate cancer by examining the effect of population density of the county of residence on treatment for clinically localized prostate cancer and quantify variation in primary treatment attributable to the county and state level. A total 138 226 men with clinically localized prostate cancer in the Surveillance, Epidemiology and End Result (SEER) database in 2005 through 2008 were analyzed. The main association of interest was between prostate cancer treatment and population density using multilevel hierarchical logit models while accounting for the random effects of counties nested within SEER regions. To quantify the effect of county and SEER region on individual treatment, the percent of total variance in treatment attributable to county of residence and SEER site was estimated with residual intraclass correlation coefficients. Men with localized prostate cancer in metropolitan counties had 23% higher odds of being treated with surgery or radiation compared with men in rural counties, controlling for number of urologists per county as well as clinical and sociodemographic characteristics. Three percent (95% confidence interval (CI): 1.2-6.2%) of the total variation in...Continue Reading

References

Dec 14, 1973·Science·J Wennberg, Gittelsohn
Jan 1, 1982·Social Science & Medicine·J E WennbergM Zubkoff
Dec 21, 2002·Urology·Alan J Wein, Eric S Rovner
Nov 8, 2003·Onkologie·J Noldus, H Huland
Oct 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tracey L KrupskiMark S Litwin
Nov 1, 2005·Cancer·Julia H Rowland, Frank Baker
Jun 22, 2006·Journal of the National Cancer Institute·Vahakn B ShahinianJames S Goodwin
May 19, 2007·The Journal of Urology·Ian ThompsonUNKNOWN AUA Prostate Cancer Clinical Guideline Update Panel
Nov 5, 2008·Cancer·Claudia HopenhaynW Jay Christian
Feb 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew R CooperbergPeter R Carroll
Mar 10, 2010·Archives of Internal Medicine·Thomas L JangDeborah Schrag
Jul 14, 2010·AORN Journal·John Zender, Christina Thell
Sep 8, 2010·The New England Journal of Medicine·Gabriel I Barbash, Sherry A Glied
Nov 9, 2010·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Dec 8, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Seth K BechisMatthew R Cooperberg
Mar 24, 2011·The Medical Journal of Australia·Peter D BaadeSuzanne K Chambers
Oct 17, 2012·The Journal of Urology·Christopher B AndersonDaniel A Barocas

❮ Previous
Next ❯

Citations

Apr 21, 2017·Current Opinion in Urology·Jathin BandariBruce L Jacobs
Nov 15, 2016·Cancer Control : Journal of the Moffitt Cancer Center·Scott M GilbertHong Xiao
Nov 3, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jennifer L MossKathleen A Cronin
Apr 12, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alicia C McDonaldMing Wang
Dec 29, 2020·JAMA Network Open·Samuel L WashingtonMatthew R Cooperberg

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.