PMID: 8592180Nov 1, 1995Paper

Variation in serotonergic inhibition of calcium channel currents in four types of rat sensory neurons differentiated by membrane properties

Journal of Neurophysiology
C G CardenasR S Scroggs

Abstract

1. Rat dorsal root ganglion (DRG) cell bodies were screened according to action potential (AP) duration, capsaicin sensitivity, expression of IH, IA, and N-, L-, and T-type Ca2+ channel currents. AP duration was measured at half of total amplitude at a membrane potential of -60 mV. Sensitivity to capsaicin was defined as production of an inward current at a holding potential (HP) of -60 mV by 1 microM capsaicin. IH was evoked by a 787-ms hyperpolarization to -110 mV from an HP of -60 mV. IA was evoked by repolarization to -60 mV after a 787-ms hyperpolarization to -110 mV. High-threshold Ca2+ channel current was evoked by a depolarization to -10 or 0 mV from an HP of -60 mV, and L- and N-type Ca2+ channel current was fractionated using selective Ca2+ channel blockers (nimodipine and omega-conotoxin GVIA). T-type Ca2+ channel current was evoked by a depolarization to -40 mV from an HP of -90 mV. Ninety-seven of the 116 DRG cells studied fit closely into one of four categories based on expression of the above characteristics. These four categories, referred to as types 1-4, are described below. 2. Type 1 DRG cells (soma diameter 24.6 +/- 0.5 microns, mean +/- SE; n = 34) had long-duration APs (average = 9.8 ms) with a prominent s...Continue Reading

Citations

May 2, 2003·British Journal of Pharmacology·Kanako HamadaHitoshi Yasuda
Apr 3, 2009·Journal of Neurophysiology·Andrea M Harriott, Michael S Gold
Dec 18, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rakesh KumarAvi Priel
Oct 2, 2019·Current Neuropharmacology·Rita Bardoni
Apr 25, 2006·The European Journal of Neuroscience·Jamie BellamyPaul L Durham
May 6, 2006·Experimental Brain Research·Florentina PenaMaria-Luiza Flonta
Feb 11, 2011·British Journal of Pharmacology·Slobodan M Todorovic, Vesna Jevtovic-Todorovic
Jan 17, 2013·Pflügers Archiv : European journal of physiology·Slobodan M Todorovic, Vesna Jevtovic-Todorovic
Jul 1, 2017·Frontiers in Molecular Neuroscience·Omer BarkaiAlexander M Binshtok
May 30, 2019·International Journal of Molecular Sciences·Isabella SalzerStefan Boehm
Sep 2, 2006·The Journal of Physiology·Shao-Gang LuMichael S Gold
Jun 4, 2004·Journal of Neurophysiology·L LiuS A Simon
Sep 12, 2015·Pflügers Archiv : European journal of physiology·Saïd M'DahomaGerald W Zamponi
Sep 14, 2004·Journal of Neurobiology·Gautam Bhave, Robert W Gereau

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