Variation in serum and plasma PTH levels in second-generation assays in hemodialysis patients: a cross-sectional study

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Dominique JolyJean-Claude P Souberbielle

Abstract

Previous reports show that parathyroid hormone (PTH) concentrations may vary widely depending on the assay used to assess PTH. In this cross-sectional study, we aim to determine the usefulness of standardizing blood handling for optimal interpretation of PTH in patients with chronic kidney disease. Diagnostic test study. Predialysis blood was sampled in 34 long-term hemodialysis patients at a single academic medical center. PTH was measured by using 6 different automated second-generation assays (Elecsys, Advia Centaur, LIAISON, Immulite, Architect, and Access assays), 3 blood specimen types (serum, EDTA plasma, and citrate plasma), and 2 consecutive days of measurement (after thawing and 18 hours later with samples having been let at room temperature). None. A mixed statistical analysis model showed that the nature of the assay (P < 0.001) and nature of the blood sample (P < 0.001) significantly influenced variability in PTH concentrations, whereas day of measurement (day 1 or 2) did not (P = 0.5). Most PTH variability was caused by observations (96.8%), then manufacturer's kit (2.5%), and last, specimen type (0.7%). PTH concentrations measured in citrate plasma were lower with every assay method used than those observed in se...Continue Reading

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Citations

Sep 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Etienne CavalierJean-Claude Souberbielle
Nov 1, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Catharine M SturgeonWendy Metcalfe
Mar 20, 2010·Clinical Chemistry and Laboratory Medicine : CCLM·Jean-Claude SouberbielleGuillaume Jean
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Feb 22, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Marie-Liesse PikettyJean-Claude Souberbielle
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