Variation in serum arylesterase, beta-glucuronidase, cathepsin L and plasminogen activators during pregnancy

Clinica Chimica Acta; International Journal of Clinical Chemistry
A CarpinteroJ A Cabezas

Abstract

To determine whether the activities of certain hydrolases (arylesterase, beta-glucuronidase, cathepsin L, plasminogen activators, arginase, glutaminase, asparaginase and adenosine deaminase) are changed during pregnancy, three groups of 15 apparently healthy women (aged 18-38 years) in their first, second and third trimester of pregnancy were compared to a control group formed of 15 non-pregnant women of similar ages. Enzyme and specific activities gradually increased from the first to the end of the third trimester of pregnancy for arylesterase and beta-glucuronidase, these increases being statistically significant (P < 0.01) in comparison to controls. However, as regards cathepsin L and plasminogen activators, the greatest increase was found in the second trimester. Arginase, glutaminase and asparaginase activities were very low and not distinguishable from the controls. In conclusion, differences in the activities of several hydrolases have been found in the sera of healthy pregnant women in comparison to controls.

References

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Citations

Mar 4, 1998·Mechanisms of Ageing and Development·M M Sánchez-Martín, J A Cabezas
Aug 24, 1999·Cancer Letters·M M Sánchez-MartínA Gómez-Alonso
Feb 26, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Gary GinsbergBabasaheb Sonawane
Jun 17, 2006·Clinical Chemistry and Laboratory Medicine : CCLM·Natàlia FerréJorge Joven
Nov 11, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Minyue DongHefeng Huang
Aug 17, 2000·Nitric Oxide : Biology and Chemistry·D T Lowe
May 5, 2017·PloS One·Adrienne CsutakDavid M Silver

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