Variation in siderophore biosynthetic gene distribution and production across environmental and faecal populations of Escherichia coli

PloS One
Laura J SearleSacha Lucchini

Abstract

Iron is essential for Escherichia coli growth and survival in the host and the external environment, but its availability is generally low due to the poor solubility of its ferric form in aqueous environments and the presence of iron-withholding proteins in the host. Most E. coli can increase access to iron by excreting siderophores such as enterobactin, which have a very strong affinity for Fe3+. A smaller proportion of isolates can generate up to 3 additional siderophores linked with pathogenesis; aerobactin, salmochelin, and yersiniabactin. However, non-pathogenic E. coli are also able to synthesise these virulence-associated siderophores. This raises questions about their role in the ecology of E. coli, beyond virulence, and whether specific siderophores might be linked with persistence in the external environment. Under the assumption that selection favours phenotypes that confer a fitness advantage, we compared siderophore production and gene distribution in E. coli isolated either from agricultural plants or the faeces of healthy mammals. This population-level comparison has revealed that under iron limiting growth conditions plant-associated isolates produced lower amounts of siderophores than faecal isolates. Additiona...Continue Reading

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Citations

Mar 26, 2016·Frontiers in Plant Science·Kareem A MosaOm Parkash Dhankher
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Datasets Mentioned

BETA
GMB69
GMB30
GMB40
GMB53
GMB88
GMB91
GMB100
GMB104

Methods Mentioned

BETA
PCR
PCRs

Software Mentioned

EcoCyc
ClustalW
ImageJ

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