PMID: 8587116Dec 1, 1995Paper

Variation in synonymous substitution rates among mammalian genes and the correlation between synonymous and nonsynonymous divergences

Journal of Molecular Evolution
T Ohta, Y Ina

Abstract

Using mammalian gene sequences, the variances in the numbers of synonymous and nonsynonymous substitutions among genes were estimated together with the correlation coefficient between the two. The expected correlation coefficient can be obtained under the neutral theory using these estimated values of the variances. The expected coefficient is found to often be one-half to two-thirds of the observed value. Possible causes for the disagreement were discussed, such as correlated selective constraints on the two types of substitutions and excess doublet mutations. The variance of mutation rate and that of selective constraint were also estimated. The results show that the coefficient of variation of the former is 0.2-0.3, whereas that of the latter is 0.7-0.9.

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Citations

Aug 1, 1997·Journal of Molecular Evolution·A L Hughes, M Yeager
Feb 15, 2001·Trends in Genetics : TIG·P D Keightley, A Eyre-Walker
Jul 20, 2002·Trends in Genetics : TIG·Martin J Lercher, Laurence D Hurst
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Jan 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Naoki OsadaJun Gojobori
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Dec 6, 2003·Genome Research·David TorrentsPeer Bork
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Sep 13, 2012·BMC Evolutionary Biology·Michael P ScherrerClaus O Wilke
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Feb 8, 2007·Genome Biology·Penelope R HaddrillBrian Charlesworth
Jun 25, 2010·Genome Biology·Kiwoong NamHans Ellegren
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Sep 29, 2011·Genetics·Toni I GossmannAdam Eyre-Walker
Sep 12, 2012·Genetics·Hiroshi AkashiTomoko Ohta

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