Variation in the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells after treatment with S-carboxymethylcysteine

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Eda SuerK Ahmed

Abstract

S-carboxymethylcysteine (S-CMC) is a mucolytic agent that can prevent respiratory infection by decreasing the attachment of respiratory pathogens to human pharyngeal epithelial cells (HPECs). Streptococcus pneumoniae is a major cause of respiratory infections. A previous study revealed that treatment of S. pneumoniae with S-CMC caused a decrease in the attachment of this bacterium to HPECs. In the present study we found that the effect of S-CMC varied according to hosts and strains. S-CMC treatment altered the surface structure of S. pneumoniae, resulting in a decrease of attachment, without affecting the virulence of the bacteria.

References

Sep 19, 2000·Infection and Immunity·K K GosinkH R Masure
Nov 8, 2006·Journal of the American Geriatrics Society·Stephen C Mitchell, Glyn B Steventon
Nov 8, 2006·Infection and Immunity·Aaron L NelsonJeffrey N Weiser

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Citations

Apr 14, 2012·Drug Metabolism Reviews·Steve C Mitchell, Glyn B Steventon
Feb 9, 2016·Multidisciplinary Respiratory Medicine·Claudio M Sanguinetti
May 17, 2014·Chest·Hoi Nam TseCee Zhung Steven Tseng
Sep 6, 2011·Journal of Medical Microbiology·Tomoko SumitomoShigetada Kawabata

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