Variation in the calpain-10 gene is associated with elevated triglyceride levels and reduced adipose tissue messenger ribonucleic acid expression in obese Swedish subjects

The Journal of Clinical Endocrinology and Metabolism
Emma CarlssonMartin Ridderstråle

Abstract

Our aim was to investigate the possible role of the type 2 diabetes susceptibility gene CAPN10 in obesity. A case control study consisting of 235 obese Swedish subjects [body mass index, 40 (35-45) kg/m(2)] and 235 controls matched for age and gender [body mass index, 22 (21-24) kg/m(2)], and a transmission disequilibrium test consisting of 116 parents-offspring trios, where the offspring was abdominally obese [waist, 100 (95-110) cm], were performed. CAPN10 mRNA expression was studied in adipose tissue biopsies from 33 of the obese subjects participating in the case control study. The CAPN10 single-nucleotide polymorphism (SNP)-43 was genotyped using PCR followed by NdeI digestion or by allelic discrimination. CAPN10 mRNA levels were quantified using real-time RT-PCR with Cyclophilin A as an internal standard. No significant associations between CAPN10 SNP-43 and obesity were seen, neither in the case control study nor in the transmission disequilibrium test, but obese subjects homozygous for the SNP-43 G allele had significantly elevated triglyceride levels compared with subjects carrying the A allele [1.7 (1.1-2.4) vs. 1.4 (1.0-2.0); P = 0.03]. The CAPN10 mRNA expression in sc fat was significantly reduced in subjects with t...Continue Reading

Citations

Mar 28, 2008·Current Hypertension Reports·Martin Ridderstråle, Emma Nilsson
May 3, 2005·Molecular Genetics and Metabolism·L J LogieM Walker
Mar 15, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·E CarlssonM Ridderstråle
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Martin RidderstråleLeif Groop
Jul 6, 2010·Annals of Human Genetics·Sandra J HasstedtUNKNOWN American Diabetes Association GENNID Study Group
Feb 11, 2014·Archives of Medical Research·Pablo PánicoPatricia Ostrosky-Wegman
Aug 30, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·José Luis MárquezLuis A Salazar
May 3, 2008·Biochimie·Biao Dong, Rihe Liu
May 22, 2007·Biochemical and Biophysical Research Communications·Eduardo López-OrduñaMiguel Cruz
Feb 6, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Jim KaputAmelia Bartholomew
Apr 19, 2005·Obesity Research·Louis PérusseClaude Bouchard
Jan 22, 2005·Annals of the New York Academy of Sciences·Finn Edler von EybenUNKNOWN Abdominal Obesity Study Group
Dec 8, 2006·Annals of the New York Academy of Sciences·Frederick HarrisDavid A Phoenix
Nov 19, 2011·Molecular Nutrition & Food Research·Pablo Perez-MartinezJose Lopez-Miranda
Jan 24, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Tanja SaarelaMarkku Laakso
Dec 25, 2012·Gene·Patricia Mendoza-LorenzoPatricia Ostrosky-Wegman
Nov 26, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Thomas NeuhausMarianne Sorger
Sep 28, 2005·Diabetes·Emma CarlssonMartin Ridderstråle
Jul 20, 2005·Diabetes/metabolism Research and Reviews·Mark D TurnerGraham A Hitman
Apr 25, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Denusa WiltgenPoli Mara Spritzer
Jun 23, 2006·American Journal of Physiology. Cell Physiology·David D ArringtonRick G Schnellmann
Mar 11, 2011·The American Journal of Clinical Nutrition·Pablo Perez-MartinezJose Lopez-Miranda
Dec 29, 2009·Archives of Biochemistry and Biophysics·Pulak KarSajal Chakraborti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.