PMID: 6163407Oct 1, 1980Paper

Variation in the catalytic potential of AMP deaminase during muscular fatigue

Archives internationales de physiologie et de biochimie
W RajendraK S Swami

Abstract

Substrate- and co-factor-dependent kinetics of AMP deaminase were studied in normal and fatigued gastrocnemius muscles of frog. Normal muscle enzyme showed greater enzyme co-factor affinity than enzyme-substrate affinity as evinced by low Kp values. Fatigue phenomenon was found to decrease the catalytic efficiency of the enzyme by lowering the enzyme-substrate affinity more than the enzyme-co-factor affinity and enhancing activation energy values. Present study elucidates the low level of operation of adenine nucleotide deamination involving AMP-deaminase reacting-system during prolonged contractile stress.

References

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