PMID: 42199Jan 1, 1979

Variation in the cell cycle time in the crypts of Lieberkühn of the mouse

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
H S Al-DewachiN A Wright

Abstract

The durations of the phases of the cell cycle were measured at different levels in the jejunal crypts of male Balb/c mice. A mean cell cycle time of 12.3 h was found for the whole crypt. In cell positions 1 and 2, the cell cycle time was 16.7 h, and this time steadily decreased to a value of between 10 and 11 h for cell positions above 11. It is concluded that basally situated crypt cells in the mouse are cycling relatively slowly, and that they form the functional stem cell pool for the crypt. These cells may also compose the potential stem cell pool which repopulates the crypt after death of proliferative cells.

References

May 1, 1975·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·C S Potten, J H Hendry
Jul 1, 1975·Cell and Tissue Kinetics·N A WrightA J Watson
Nov 1, 1974·Cell and Tissue Kinetics·H S Al-DewachiA J Watson
Jun 1, 1974·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J H Hendry, C S Potten
Jun 1, 1965·The Journal of Experimental Zoology·J D Thrasher, R C Greulich

Citations

May 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J M Huard, J E Schwob
Jun 1, 1986·Biophysical Journal·Matthew Bjerknes
Oct 12, 2010·Science·Carlos Lopez-GarciaDouglas J Winton
Jan 1, 1980·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H S Al-DewachiA J Watson
Dec 1, 1990·International Journal of Radiation Biology·C S Potten
Feb 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·C S Potten
Jan 1, 1990·International Journal of Radiation Biology·C S PottenS A Roberts
Oct 1, 2009·Cell Proliferation·C S PottenN A Wright
Jul 1, 1987·Cell and Tissue Kinetics·E K Lund, M W Smith
Jan 1, 1982·Medical and Pediatric Oncology·M G Pallavicini, J W Gray
Sep 30, 2006·Developmental Biology·Matthew Bjerknes, Hazel Cheng
Jan 1, 1990·European Archives of Psychiatry and Neurological Sciences·G EsserH Weinel
Nov 1, 1980·Cell and Tissue Kinetics·N A Wright, D R Appleton
Nov 7, 2012·Indian Dermatology Online Journal·Shambulingappa PallagattiRavinder Singh
Feb 25, 2011·Bulletin of Mathematical Biology·S Seirin LeeR E Baker
Sep 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S Tsubouchi, C S Potten

Related Concepts

Cell Cycle
Structure of Intestinal Gland
Jejunum
Mice, Inbred BALB C

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