Variation in the IL1B, TNF and IL6 genes and individual susceptibility to prosthetic joint infection.

BMC Immunology
Anna StahelovaJiri Gallo

Abstract

Prosthetic joint infection (PJI) is an important failure mechanism of total joint arthroplasty (TJA). Here we examine whether the particular genetic variants can lead to increased susceptibility to PJI development. We conducted a genetic-association study to determine whether PJI could be associated with functional cytokine gene polymorphisms (CGP) influencing on innate immunity response. A case-control design was utilized and previously published criteria for PJI were included to distinguish between cases and control subjects with/without TJA. Six single nucleotide polymorphisms (SNPs) located in the genes for interleukin-1beta (SNP: IL1B-511, +3962), tumour necrosis factor alpha (TNF-308, -238) and interleukin-6 (IL6-174, nt565) were genotyped in 303 Caucasian (Czech) patients with TJA (89 with PJI / 214 without PJI), and 168 unrelated healthy Czech individuals without TJA. The results showed that carriers of the less common IL1B-511*T allele were overrepresented in the group of TJA patients with PJI (69%) in comparison with those that did not develop PJI (51%, p = 0.006, p(corr) = 0.037) and with healthy controls (55%, p = 0.04, p(corr) = N.S.). There was no significant difference in the distribution of the remaining five in...Continue Reading

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Citations

Feb 19, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Frantisek MrazekMartin Petrek
Aug 15, 2014·International Journal of Molecular Sciences·Jiri GalloCalin S Moucha
Apr 4, 2014·Clinical Microbiology Reviews·Aaron J Tande, Robin Patel
May 16, 2014·Journal of Applied Biomaterials & Functional Materials·Mayar Al Mohajer, Rabih O Darouiche

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Methods Mentioned

BETA
primary hip arthroplasties
total hip arthroplasty
genotyping
PCR
electrophoresis

Software Mentioned

ARLEQUIN
STREGA
STROBE
GRISP

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