PMID: 4895565Apr 1, 1969Paper

Variation in the N-terminal sequence of heavy chains of immunoglobulin G from rabbits of different allotype

The Biochemical Journal
J M Wilkinson

Abstract

The sequences of the N-terminal peptides prepared by Pronase digestion of the heavy chain of rabbit immunoglobulin G of allotype Aa1, Aa2 and Aa3 were determined and were shown to be related to the allotype. An N-terminal fragment of about 34 residues was also prepared from the allotype heavy chains, by cleavage with cyanogen bromide; the yield varied with the allotype. The sequences of the cyanogen bromide fragments from the Aa1 and Aa3 heavy chains contain allotype-related variations similar to those found in the N-terminal Pronase peptides, and these sequences are thought to be representative of the whole heavy-chain populations. There is about 60% homology between the two sequences, and superimposed on the differences between them there are a number of positions within each sequence at which at least two amino acids are present.

Citations

Oct 27, 1986·FEBS Letters·R J Vandenberg, S B Easterbrook-Smith
Jul 25, 1970·Nature·J A Gally, G M Edelman
Jan 1, 1974·Scandinavian Journal of Immunology·A J Cunningham, L M Pilarski
Dec 31, 1971·Annals of the New York Academy of Sciences·F W PutnamH Köhler
Dec 31, 1971·Annals of the New York Academy of Sciences·E A Kabat, T T Wu
Feb 1, 1983·Bioscience Reports·S B Easterbrook-Smith
Sep 1, 1982·European Journal of Biochemistry·V M TischenkoP L Privalov
Dec 1, 1980·FEBS Letters·S B Easterbrook-Smith, R A Dwek
Dec 31, 1971·Annals of the New York Academy of Sciences·L HoodC W Todd
Dec 31, 1971·Annals of the New York Academy of Sciences·J W Prahl, C W Todd
Dec 1, 1989·Immunology and Cell Biology·J M WhitelockJ G Lyons
Dec 1, 1972·European Journal of Immunology·A Gilman-Sachs, S Dray
Aug 1, 1977·FEBS Letters·K J WillanR A Dwek
Feb 1, 1970·European Journal of Biochemistry·A Bourgois, M Fougereau
Jan 1, 1974·Scandinavian Journal of Immunology·J D Capra, J M Kehoe
Feb 1, 1970·Biochemical Genetics·W J Mandy, C W Todd
Jun 1, 1976·European Journal of Immunology·F FranĕkJ M Kehoe
Jan 1, 1970·Progress in Biophysics and Molecular Biology·C Milstein, J R Pink
Mar 1, 1987·Molecular Immunology·H HaouasP A Cazenave
Aug 1, 1991·Molecular Immunology·B D Wines, S B Easterbrook-Smith
Feb 17, 1970·Biochimica Et Biophysica Acta·P C MontgomeryJ H Rockey
Apr 22, 1986·Biochimica Et Biophysica Acta·A Comis, S B Easterbrook-Smith
Mar 18, 1987·Biochimica Et Biophysica Acta·M N McCall, S B Easterbrook-Smith
May 1, 1974·Immunochemistry·S K McBurnette, W J Mandy

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