Variation in the prion protein gene (PRNP) sequence of wild deer in Great Britain and mainland Europe

Veterinary Research
Amy L RobinsonFiona Houston

Abstract

Susceptibility to prion diseases is largely determined by the sequence of the prion protein gene (PRNP), which encodes the prion protein (PrP). The recent emergence of chronic wasting disease (CWD) in Europe has highlighted the need to investigate PRNP gene diversity in European deer species, to better predict their susceptibility to CWD. Here we report a large genetic survey of six British deer species, including red (Cervus elaphus), sika (Cervus nippon), roe (Capreolus capreolus), fallow (Dama dama), muntjac (Muntiacus reevesii), and Chinese water deer (Hydropotes inermis), which establishes PRNP haplotype and genotype frequencies. Two smaller data sets from red deer in Norway and the Czech Republic are also included for comparison. Overall red deer show the most PRNP variation, with non-synonymous/coding polymorphisms at codons 98, 168, 226 and 247, which vary markedly in frequency between different regions. Polymorphisms P168S and I247L were only found in Scottish and Czech populations, respectively. T98A was found in all populations except Norway and the south of England. Significant regional differences in genotype frequencies were observed within both British and European red deer populations. Other deer species showed ...Continue Reading

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Citations

Jul 7, 2020·EFSA Journal·UNKNOWN EFSA Panel on Biological Hazards (BIOHAZ)Marion M Simmons
Mar 7, 2021·International Journal of Molecular Sciences·Maria Immaculata ArifinSabine Gilch
Aug 5, 2021·Transboundary and Emerging Diseases·Mariella Evelyn GüereKnut Håkon Røed
Oct 9, 2021·Veterinary Research·Katayoun Moazami-GoudarziVincent Béringue

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Datasets Mentioned

BETA
MK103016
MK103017
MK103019
MK103027

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

Seqscape
Lasergene
DNAStar
Chromas
MEGA7

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