Variation in the probability of cardiac complications with radiation technique in early breast cancer

The British Journal of Radiology
P A CanneyT E Wheldon

Abstract

Cardiac damage is recognized to be a potentially serious side effect of breast cancer radiotherapy, the risk of which may be reduced by the choice of appropriate radiotherapy technique. We have previously described variation in physical dose to the heart dependent upon radiotherapy technique. In this paper we report the calculated improvement in normal tissue complication probability (NTCP) (for cardiac damage) achievable by these methods. Cardiac doses were calculated from dose-volume histograms (DVHs) using a "Helax" planning system for 11 patients with left-sided tumours and 5 patients with right-sided tumours. The DVH reduction algorithm of Lyman and Wolbarst [1989] was applied to each DVH to produce a value for the NTCP. For left-sided tumours, mean NTCP with the standard technique was 7.4 +/- 5.6% (range 0.6-17%) and for the optimum technique mean NTCP was 0.3 +/- 0.6% (range 0-2%) (p < 0.003 for the difference between the two techniques): a predicted reduction in late cardiac complications of 23-fold, which is not clearly evident from viewing the DVH raw data.

References

Aug 1, 1992·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C S HamiltonJ W Denham
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·L E RutqvistH Johansson
May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·B EmamiM Wesson
Aug 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J T Lyman, A B Wolbarst
May 1, 1986·International Journal of Radiation Oncology, Biology, Physics·H HøstM Loeb
Jan 1, 1987·International Journal of Radiation Oncology, Biology, Physics·J T Lyman, A B Wolbarst
Mar 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J CuzickH Host

❮ Previous
Next ❯

Citations

Feb 22, 2005·Medical Physics·Shiva K DasLawrence B Marks
Feb 7, 2013·The British Journal of Radiology·R B GoodyG G Hanna
Jul 14, 2011·The British Journal of Radiology·S VivekanandanD A L Morgan
Oct 12, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Kurtz, UNKNOWN EUSOMA Working Party
Jun 23, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P GiraudUNKNOWN les centres investigateurs du Stic
Sep 8, 2009·Seminars in Radiation Oncology·Meena S Moran, Bruce G Haffty
Sep 4, 2007·Cancer Treatment Reviews·Elzbieta Senkus-Konefka, Jacek Jassem
Jun 9, 2004·International Journal of Radiation Oncology, Biology, Physics·Guido BaroniAntonio Pedotti
Dec 1, 2015·Seminars in Radiation Oncology·Debra Nana Yeboa, Suzanne Buckley Evans
Oct 18, 2005·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M G SaliouJ M Cosset
Nov 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Carolyn W TaylorSarah C Darby
Aug 5, 2016·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Waseem RazaPunita Lal
Jul 26, 2018·The British Journal of Radiology·Yoshihiro UedaIndra J Das

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.