Abstract
Among patients with stage I breast cancer, there is significant uncertainty concerning the optimal threshold at which to consider chemotherapy, and when considered, there is controversy regarding whether to consider non-intensive versus intensive regimens. The authors examined the types and costs of adjuvant chemotherapy received among patients with stage I breast cancer. The current study was a prospective cohort study including patients with stage I breast cancer who were treated at a National Comprehensive Cancer Network center from 2000 through 2009. Stage was defined according to the version of the American Joint Committee on Cancer Staging Manual applicable at the time of diagnosis. Stratifying by human epidermal growth factor receptor 2 (HER2), the authors examined the percentage of patients receiving intensive versus non-intensive chemotherapy regimens and the factors associated with type of chemotherapy administered using multivariable logistic regression. Costs of the most common regimens were estimated. Of 8907 patients, 33% received adjuvant chemotherapy. Among those individuals, there was an increase in the use of intensive chemotherapy within the last decade, from 31% in 2000 through 2005 to 63% in 2008 through 20...Continue Reading
References
Jan 1, 1987·Journal of Chronic Diseases·M E CharlsonC R MacKenzie
Nov 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P P RosenL Norton
Jan 1, 1996·Medical Care·J N KatzD W Bates
May 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen K ChiaIvo A Olivotto
Dec 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen E JonesLina Asmar
Oct 12, 2007·The New England Journal of Medicine·Daniel F HayesUNKNOWN Cancer and Leukemia Group B (CALGB) Investigators
Nov 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emer O HanrahanVicente Valero
May 13, 2008·International Journal of Radiation Oncology, Biology, Physics·Rinaa S PungliaJane C Weeks
Oct 14, 2011·The New England Journal of Medicine·Dennis SlamonUNKNOWN Breast Cancer International Research Group
Dec 14, 2011·Lancet·R PetoK Pritchard
May 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sharon H GiordanoJames S Goodwin
Aug 7, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Jun 4, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ines Vaz-LuisNancy U Lin
Jan 8, 2015·The New England Journal of Medicine·Sara M TolaneyEric P Winer
Nov 13, 2015·The New England Journal of Medicine
Citations
Jul 30, 2016·The Breast : Official Journal of the European Society of Mastology·Arlindo R FerreiraInês Vaz-Luís
Oct 11, 2016·The Breast : Official Journal of the European Society of Mastology·Romualdo Barroso-SousaNancy U Lin
Oct 13, 2016·The New England Journal of Medicine·Javid J Moslehi
Oct 2, 2019·Journal of Oncology Practice·Jon M RichardsJohn W Peabody
Apr 25, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ines Vaz-LuisNancy U Lin
Nov 5, 2017·Oncotarget·Qiao LiPin Zhang