Variation in vaginal immune parameters and microbial hydrolytic enzymes in bacterial vaginosis positive pregnant women with and without Mobiluncus species

American Journal of Obstetrics and Gynecology
Jennifer F CulhaneSabina Cauci

Abstract

This study was undertaken to assess if levels of interleukin-1beta (IL-1beta), IL-8, sialidase, prolidase and immunoglobulin A against Gardenerella vaginalis hemolysin (anti-Gvh IgA) in vaginal secretions differ between BV+ women with (M+) and without (M-) Mobiluncus spp. Vaginal secretions were obtained from 265 women at their first prenatal care visit and assessed for all study parameters. Gram stain evaluation using Nugent criteria was performed and coinfection with sexually transmitted infections determined. Differences between BV+/M+ and BV+/M- women were evaluated using the chi2 statistic or Mann-Whitney test. Of the 265 BV+ women, 43% (n = 113) were M+ of which 97% (n = 110) had Nugent scores of 9 or 10 . BV+/M+ women had elevated levels of sialidase (median value: 4.11 nmol vs 1.91 nmol of converted substrate; P = .003) but no difference in prolidase, anti-Gvh IgA, IL-1beta, IL-8, levels were found between the two groups. BV+/M- women had significantly higher rates of coinfection with Trichomonas vaginalis. BV+/M+ women have higher vaginal concentrations of sialidase and lower rates of T. vaginalis compared with BV+/M- women. Further research is needed to assess the association of this, and other, microbiologic profiles...Continue Reading

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Citations

Mar 1, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M TorricelliUNKNOWN Italian Pre-Term Network Study Group
May 17, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Laura M EnsignJustin Hanes
Oct 2, 2012·Journal of Reproductive Immunology·Kathryn E RoyseSadeep Shrestha
Oct 26, 2012·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Joan Rosen BlochMichelle O'Connor Kensey
Dec 24, 2011·Gynécologie, obstétrique & fertilité·J-P Menard, F Bretelle
Jul 30, 2011·Seminars in Perinatology·Jennifer F Culhane, Robert L Goldenberg
Jul 24, 2008·American Journal of Reproductive Immunology : AJRI·Jennifer Flatow CulhaneSabina Cauci
May 17, 2014·American Journal of Reproductive Immunology : AJRI·Caroline Mitchell, Jeanne Marrazzo
Nov 9, 2010·American Journal of Obstetrics and Gynecology·Sabina Cauci, Jennifer Flatow Culhane
Oct 22, 2008·American Journal of Obstetrics and Gynecology·Thaddeus P WatersJennifer F Culhane
Oct 29, 2008·Infectious Disease Clinics of North America·Paul Nyirjesy
Feb 13, 2016·Clinical Microbiology Reviews·Andrew B OnderdonkRaina N Fichorova
Nov 17, 2007·Current Opinion in Obstetrics & Gynecology

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