Abstract
This study was undertaken to assess if levels of interleukin-1beta (IL-1beta), IL-8, sialidase, prolidase and immunoglobulin A against Gardenerella vaginalis hemolysin (anti-Gvh IgA) in vaginal secretions differ between BV+ women with (M+) and without (M-) Mobiluncus spp. Vaginal secretions were obtained from 265 women at their first prenatal care visit and assessed for all study parameters. Gram stain evaluation using Nugent criteria was performed and coinfection with sexually transmitted infections determined. Differences between BV+/M+ and BV+/M- women were evaluated using the chi2 statistic or Mann-Whitney test. Of the 265 BV+ women, 43% (n = 113) were M+ of which 97% (n = 110) had Nugent scores of 9 or 10 . BV+/M+ women had elevated levels of sialidase (median value: 4.11 nmol vs 1.91 nmol of converted substrate; P = .003) but no difference in prolidase, anti-Gvh IgA, IL-1beta, IL-8, levels were found between the two groups. BV+/M- women had significantly higher rates of coinfection with Trichomonas vaginalis. BV+/M+ women have higher vaginal concentrations of sialidase and lower rates of T. vaginalis compared with BV+/M- women. Further research is needed to assess the association of this, and other, microbiologic profiles...Continue Reading
References
Jun 1, 1989·Antimicrobial Agents and Chemotherapy·B M JonesB I Duerden
Feb 1, 1986·Obstetrics and Gynecology·M G GravettK K Holmes
Feb 1, 1987·Antimicrobial Agents and Chemotherapy·C A Spiegel
Dec 28, 1995·The New England Journal of Medicine·J C HauthR L Copper
Dec 28, 1995·The New England Journal of Medicine·S L HillierA V Rao
Mar 1, 1997·Journal of the Society for Gynecologic Investigation·H M ImseisM Erikson
Apr 16, 1998·American Journal of Obstetrics and Gynecology·S CauciF Quadrifoglio
Nov 17, 1998·The Journal of Infectious Diseases·S CauciF Quadrifoglio
Jul 23, 1999·BMJ : British Medical Journal·S G RalphJ D Wilson
Feb 24, 2000·The New England Journal of Medicine·J C CareyM Varner
May 18, 2000·The New England Journal of Medicine·R L GoldenbergW W Andrews
May 23, 2002·The Journal of Infectious Diseases·Sabina CauciFranco Quadrifoglio
Oct 18, 2002·Obstetrics and Gynecology·Roberta B NessPeter Rice
Jan 9, 2003·Journal of Clinical Microbiology·Sabina CauciSecondo Guaschino
Jan 17, 2003·Molecular Human Reproduction·Sabina CauciFranco Quadrifoglio
Mar 14, 2003·American Journal of Obstetrics and Gynecology·John C HauthBaha Sibai
Mar 15, 2003·Obstetrics and Gynecology·Ronald F LamontPaul Bassett
Mar 28, 2003·Lancet·Austin UgwumaduPhillip Hay
Nov 13, 2004·Current Infectious Disease Reports·Sabina Cauci
Feb 8, 2005·American Journal of Obstetrics and Gynecology·Sabina CauciSecondo Guaschino
Sep 10, 2005·American Journal of Obstetrics and Gynecology·Leonardo PereiraPaul Nyirjesy
Nov 4, 2005·The New England Journal of Medicine·Sharon L Hillier
Citations
Mar 1, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M TorricelliUNKNOWN Italian Pre-Term Network Study Group
May 17, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Laura M EnsignJustin Hanes
Oct 2, 2012·Journal of Reproductive Immunology·Kathryn E RoyseSadeep Shrestha
Oct 26, 2012·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Joan Rosen BlochMichelle O'Connor Kensey
Dec 24, 2011·Gynécologie, obstétrique & fertilité·J-P Menard, F Bretelle
Jul 30, 2011·Seminars in Perinatology·Jennifer F Culhane, Robert L Goldenberg
Jul 24, 2008·American Journal of Reproductive Immunology : AJRI·Jennifer Flatow CulhaneSabina Cauci
May 17, 2014·American Journal of Reproductive Immunology : AJRI·Caroline Mitchell, Jeanne Marrazzo
Nov 9, 2010·American Journal of Obstetrics and Gynecology·Sabina Cauci, Jennifer Flatow Culhane
Oct 22, 2008·American Journal of Obstetrics and Gynecology·Thaddeus P WatersJennifer F Culhane
Aug 24, 2007·American Journal of Obstetrics and Gynecology·Sabina CauciKelly McCollum
Oct 29, 2008·Infectious Disease Clinics of North America·Paul Nyirjesy
Feb 27, 2018·BioMed Research International·Sang Soo SeoJae Kwan Lee
Feb 13, 2016·Clinical Microbiology Reviews·Andrew B OnderdonkRaina N Fichorova
Feb 23, 2007·Molecular Human Reproduction·Sabina CauciSecondo Guaschino
Jul 9, 2020·Frontiers in Medicine·Yuanhui HeHuixia Yang
Nov 17, 2007·Current Opinion in Obstetrics & Gynecology