Variation in vertebrate cis-regulatory elements in evolution and disease

Transcription
Adam Thomas Douglas, Robert D Hill

Abstract

Much of the genetic information that drives animal diversity lies within the vast non-coding regions of the genome. Multi-species sequence conservation in non-coding regions of the genome flags important regulatory elements and more recently, techniques that look for functional signatures predicted for regulatory sequences have added to the identification of thousands more. For some time, biologists have argued that changes in cis-regulatory sequences creates the basic genetic framework for evolutionary change. Recent advances support this notion and show that there is extensive genomic variability in non-coding regulatory elements associated with trait variation, speciation and disease.

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Citations

Sep 1, 2015·Seminars in Cell & Developmental Biology·Vanessa R Paixão-CôrtesMaria Cátira Bortolini
May 8, 2018·Nucleic Acids Research·Meng NiuZhengchang Su
Mar 4, 2021·Development Genes and Evolution·Irfan HussainAmir Ali Abbasi
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Jul 1, 2021·Genome Biology·Julius JuddCédric Feschotte

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