Variation of endothelium-related hemostatic factors during sepsis

Microcirculation : the Official Journal of the Microcirculatory Society, Inc
Ioannis VasileiadisAntonia Koutsoukou

Abstract

The thrombomodulin/protein C and VWF/ADAMTS-13 pathways are disturbed in sepsis and have been implicated in the coagulation disorders that characterize the septic syndrome. We aimed to assess the variation of these endothelial parameters during sepsis and their putative association with outcome, in critically ill, septic patients. We monitored 34 septic patients, 23 of whom improved (group A) while 11 deteriorated (group B). We assessed ADAMTS-13 levels, VWF activity, soluble thrombomodulin, and protein C activity upon admission to the ICU (time point 0) and at the time of a change in the clinical condition (remission or deterioration, time point 1). In group A, thrombomodulin and VWF increased at time point 1 compared to time point 0 (P = 0.011, P = 0.028, respectively). In group B, protein C and ADAMTS-13 significantly decreased (P = 0.023, P = 0.026, respectively), while VWF, VWF/ADAMTS-13 ratio, and the thrombomodulin/protein C ratio increased (P = 0.02, P = 0.002, P = 0.01, respectively). Protein C (> or ≤17%) and ADAMTS-13 percentage difference (> or ≤22%) were independently associated with sepsis outcome among the endothelial variables tested. An ongoing endothelial/hemostatic disorder was established during sepsis, obse...Continue Reading

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Citations

May 23, 2020·International Journal of Laboratory Hematology·Albert HuismanNuray Kusadasi
Sep 4, 2020·TH Open : Companion Journal to Thrombosis and Haemostasis·Giovanni L TisciaUNKNOWN CSS COVID-19 Group
Oct 28, 2019·Journal of Clinical Medicine·Ioannis VasileiadisAntonia Koutsoukou
Jan 28, 2021·International Journal of Laboratory Hematology·Mario Rodríguez RodríguezJoaquín Martinez-Lopez
Nov 5, 2021·Pediatric Research·Sherrill D CaprarolaMelania M Bembea

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