Abstract
The thrombomodulin/protein C and VWF/ADAMTS-13 pathways are disturbed in sepsis and have been implicated in the coagulation disorders that characterize the septic syndrome. We aimed to assess the variation of these endothelial parameters during sepsis and their putative association with outcome, in critically ill, septic patients. We monitored 34 septic patients, 23 of whom improved (group A) while 11 deteriorated (group B). We assessed ADAMTS-13 levels, VWF activity, soluble thrombomodulin, and protein C activity upon admission to the ICU (time point 0) and at the time of a change in the clinical condition (remission or deterioration, time point 1). In group A, thrombomodulin and VWF increased at time point 1 compared to time point 0 (P = 0.011, P = 0.028, respectively). In group B, protein C and ADAMTS-13 significantly decreased (P = 0.023, P = 0.026, respectively), while VWF, VWF/ADAMTS-13 ratio, and the thrombomodulin/protein C ratio increased (P = 0.02, P = 0.002, P = 0.01, respectively). Protein C (> or ≤17%) and ADAMTS-13 percentage difference (> or ≤22%) were independently associated with sepsis outcome among the endothelial variables tested. An ongoing endothelial/hemostatic disorder was established during sepsis, obse...Continue Reading
References
Mar 1, 1992·Chest·F FourrierP Lestavel
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
May 1, 1993·Chest·J A LorenteA García-Avello
Jul 1, 1996·Intensive Care Medicine·J L VincentL G Thijs
Dec 1, 2000·Critical Care Medicine·J LeclercB Vallet
Mar 28, 2001·Critical Care Medicine·F B TaylorG T Kinasewitz
Oct 24, 2002·Blood·Jing-fei DongJosé A López
Nov 14, 2006·Critical Care : the Official Journal of the Critical Care Forum·Trung C Nguyen, Joseph A Carcillo
Sep 4, 2007·Journal of Thrombosis and Haemostasis : JTH·J A Kremer HovingaB Lämmle
Oct 19, 2007·Critical Care Medicine·Kenneth MartinDominique Baruch
Apr 24, 2008·Critical Care Medicine·Shu-Min LinHan-Pin Kuo
Oct 21, 2009·Journal of Hematology & Oncology·Rakshit PanwarGoce Dimeski
May 6, 2010·Intensive Care Medicine·H Ait-OufellaG Offenstadt
Aug 14, 2010·Journal of Thrombosis and Haemostasis : JTH·I BadirouC V Denis
Jun 24, 2011·Science Translational Medicine·Neil M GoldenbergWarren L Lee
Nov 9, 2011·Thrombosis Research·Nicola SemeraroMario Colucci
Feb 9, 2012·Seminars in Thrombosis and Hemostasis·Nancy TurnerJoel Moake
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalAndrés Felipe Cardona
Mar 14, 2013·Shock·Hidetada FukushimaKazuo Okuchi
Nov 10, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Dunja M MihajlovicSnezana V Brkic
Jan 25, 2014·Blood·Agon HyseniMark Roest
Feb 3, 2015·Shock·Jesús AibarJosep Maria Nicolás
Feb 24, 2015·Journal of Intensive Care·Takayuki Ikezoe
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Apr 23, 2016·Medicine·Jainn-Jim LinCheng-Hsun Chiu
Apr 24, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Marcos MirandaEliete Bouskela
Oct 21, 2016·Intensive Care Medicine·Federico PappalardoAlberto Zangrillo
Apr 28, 2017·Clinical and Investigative Medicine. Médecine Clinique Et Experimentale·M Feroz AzfarHameed Ullah
Aug 15, 2017·Anaesthesiology Intensive Therapy·Małgorzata Lipinska-Gediga
Citations
May 23, 2020·International Journal of Laboratory Hematology·Albert HuismanNuray Kusadasi
Aug 18, 2020·Journal of Intensive Care Medicine·Xiao HuangXiaozhi Wang
Sep 4, 2020·TH Open : Companion Journal to Thrombosis and Haemostasis·Giovanni L TisciaUNKNOWN CSS COVID-19 Group
Oct 28, 2019·Journal of Clinical Medicine·Ioannis VasileiadisAntonia Koutsoukou
Jan 28, 2021·International Journal of Laboratory Hematology·Mario Rodríguez RodríguezJoaquín Martinez-Lopez
Nov 5, 2021·Pediatric Research·Sherrill D CaprarolaMelania M Bembea