Variation of genes encoding KAT1, AADAT and IDO1 as a potential risk of depression development.

European Psychiatry : the Journal of the Association of European Psychiatrists
Paulina WignerTomasz Sliwinski

Abstract

Numerous data suggests that the disorders of tryptophan catabolites (TRYCATs) pathway, including a decreased level of tryptophan or evaluated concentration of harmful TRYCATs -kynurenine, quinolinic acid, 3-hydroxyanthranilic acid, 3-hydroxytryptophan - may cause the occurrence of DD symptoms. In this work, we assessed the relationship between single-nucleotide polymorphisms (SNPs) of KAT1, KAT2 and IDO1 gene encoding, and the risk of depression development. Our study was performed on the DNA isolated from peripheral blood of 281 depressed patients and 236 controls. We genotyped, by using TaqMan probes, four polymorphisms: c.*456G > A of KAT1 (rs10988134), c.975-7T > C of AADAT (rs1480544), c.-1849C > A (rs3824259) and c.-1493G > C(rs10089084)of IDO1. We found that only the A/A genotype of c.*456G > A - KAT1 (rs10988134) increased the risk of depression occurrence. Interestingly, when we stratified the study group according to gender, this relationship was present only in male population. However, a gene-gene analysis revealed a link between the T/T-C/C genotype of c.975-7T > C - AADAT (rs1480544)or c.-1493G > C - IDO1 (rs10089084) and C/C-C/A genotype of c.975-7T > C - AADAT (rs1480544)and c. -1849C > A - IDO1 (rs3824259) and ...Continue Reading

References

Apr 1, 1976·Journal of Biochemistry·O Hayaishi
Apr 16, 1990·Biochemical and Biophysical Research Communications·W Dai, S L Gupta
Sep 1, 1980·The Biochemical Journal·Y WatanabeO Hayaishi
Aug 1, 1994·Trends in Biochemical Sciences·C J Decker, R Parker
Jan 1, 1996·Annual Review of Biochemistry·A Jacobson, S W Peltz
Sep 29, 1999·Immunology Today·A L Mellor, D H Munn
Aug 25, 2001·Journal of Neurochemistry·G J GuilleminB J Brew
Oct 31, 2002·Nature Reviews. Drug Discovery·Trevor W Stone, L Gail Darlington
Oct 31, 2002·Human Psychopharmacology·John F. Cryan, Brian E. Leonard
Feb 26, 2003·Psychotherapy and Psychosomatics·Koen Demyttenaere, Jürgen De Fruyt
Mar 21, 2003·Journal of Affective Disorders·Ronald C Kessler
Sep 19, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Cory M RobinsonJoseph M Carlin
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
May 5, 2004·Expert Reviews in Molecular Medicine·Ludmila Prokunina, Marta E Alarcón-Riquelme
Jun 23, 2004·Advances in Experimental Medicine and Biology·Colin R MacKenzieWalter Däubener
Nov 23, 2006·Annals of Internal Medicine·Dan M RodenUNKNOWN Pharmacogenetics Research Network
Sep 27, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S Marsh
May 15, 2008·Journal of Neuroinflammation·Christopher J HenryJonathan P Godbout
Oct 15, 2009·Cellular and Molecular Life Sciences : CMLS·Qian HanJianyong Li
Mar 12, 2010·Molecular Brain·Saebom LeeSang Ki Park
Apr 22, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Vilma GabbayLeonard Liebes
Jul 6, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michael Maes
Apr 9, 2011·BMC Medical Genetics·Fladjule Rejane Soares de SouzaLucymara Fassarella Agnez-Lima
Jun 23, 2011·Brain, Behavior, and Immunity·Amanda Galvão-de AlmeidaCamila Guindalini
Jul 26, 2011·Journal of Neural Transmission·Vilma GabbayLeonard Liebes
Jan 1, 2010·Indian Journal of Psychological Medicine·M S Reddy
Oct 30, 2012·Trends in Immunology·David H Munn, Andrew L Mellor
Dec 25, 2012·Brain, Behavior, and Immunity·Masaaki IwataRonald S Duman
Jan 4, 2013·BMC Psychiatry·Hung-Yen LinYung-Chieh Yen
Apr 23, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michel Hamon, Pierre Blier
Jul 3, 2013·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·K PreissD Clarke
Apr 1, 2016·American Journal of Physiology. Cell Physiology·Maja SchlittlerDaniel C Andersson

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