Variation of growth in the production of the BCG vaccine and the association with the immune response. An observational study within a randomised trial

Vaccine
Sofie Biering-SørensenKaare Robert Hasløv

Abstract

Bacille Calmette-Guérin (BCG) vaccine has beneficial non-specific effects on overall survival. After BCG vaccination, positive PPD response and scar formation are associated with increased survival. During a trial randomising low-birth-weight neonates to BCG at birth or the usual delayed BCG, the manufacturer of the BCG vaccine experienced a period with relatively slow growth rate of the BCG. We investigated the association between growth rate of BCG when manufacturing the vaccine and its capability to induce immune responses in vivo and in vitro. 1633 neonates were randomised to BCG at birth and examined for scar at 12 months; a subgroup was tested for PPD response at 2 and 6 months. The BCG batches from the Slow growth period were compared with the precedent and subsequent Normal growth batches with regard to prevalence and size of BCG scar and PPD response. We also tested the effect of batches on in vitro cytokine responses. At 12 months, the Slow growth batches were associated with higher BCG scar prevalence (98.2%) than the precedent batches (92.3%, p=0.01) but the prevalence remained high after return to normal growth (98.8%, p=0.52). The Slow growth batches were associated with larger scar size (5.0mm) than precedent (4....Continue Reading

References

Jul 1, 1992·Archives of Disease in Childhood·P HengsterG Menardi
Aug 1, 1995·The Journal of Infectious Diseases·L KrögerM L Katila
Feb 1, 1997·Annals of Internal Medicine·J PouchotP Vinceneux
Mar 6, 1999·Vaccine·M A Behr, P M Small
Sep 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D Menzies
Feb 24, 2001·BMJ : British Medical Journal·P Fine
Mar 3, 2001·Vaccine·J BedwellJ A Bygraves
Mar 21, 2002·The Lancet Infectious Diseases·Marcel A Behr
Jun 15, 2004·The Pediatric Infectious Disease Journal·Adam RothPeter Aaby
Jan 22, 2005·International Journal of Epidemiology·Adam RothPeter Aaby
Jul 29, 2006·The Pediatric Infectious Disease Journal·Peter AabyPer Ashorn
Aug 1, 2006·Epidemiology·Adam RothPeter Aaby
Nov 1, 2006·Biologicals : Journal of the International Association of Biological Standardization·Keigo ShibayamaSaburo Yamamoto
Mar 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Roland BroschStewart T Cole
Jul 12, 2008·FEMS Microbiology Reviews·Nicole RitzNigel Curtis
May 30, 2009·PloS One·Dany J V BesteJohnjoe McFadden
Jan 23, 2010·Biologicals : Journal of the International Association of Biological Standardization·UNKNOWN WHO
Nov 11, 2011·American Journal of Respiratory and Critical Care Medicine·Nicole RitzNigel Curtis
Dec 23, 2011·The Pediatric Infectious Disease Journal·Sofie Biering-SørensenChristine Stabell Benn
Dec 23, 2011·Vaccine·Manjunatha M VenkataswamySteven A Porcelli
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Johanneke KleinnijenhuisMihai G Netea
May 18, 2013·Trends in Immunology·Christine S BennPeter Aaby
Jul 23, 2013·European Journal of Clinical Investigation·Mihai G Netea
Dec 2, 2015·Saudi Medical Journal·Alamin Berhanu, Hashim Bin Salleeh

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Citations

Jun 11, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Frank Shann
Sep 18, 2015·Journal of Immunology Research·Elfi TöpferPaola Italiani
Mar 29, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bastiaan A BlokMihai G Netea
Sep 12, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T N NissenO Pryds
Feb 18, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Bastiaan A BlokMihai G Netea
Sep 29, 2017·Frontiers in Immunology·Hazel M Dockrell, Steven G Smith

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