Variation of prevalence of malaria, parasite density and the multiplicity of Plasmodium falciparum infection throughout the year at three different health centers in Brazzaville, Republic of Congo

BMC Infectious Diseases
Pembe Issamou MayengueHenri Joseph Parra

Abstract

In the Republic of Congo, hot temperature and seasons distortions observed may impact the development of malaria parasites. We investigate the variation of malaria cases, parasite density and the multiplicity of Plasmodium falciparum infection throughout the year in Brazzaville. From May 2015 to May 2016, suspected patients with uncomplicated malaria were enrolled at the Hôpital de Mfilou, CSI « Maman Mboualé», and the Laboratoire National de Santé Publique. For each patient, thick blood was examined and parasite density was calculated. After DNA isolation, MSP1 and MSP2 genes were genotyped. A total of 416, 259 and 131 patients with suspected malaria were enrolled at the CSI «Maman Mboualé», Hôpital de Mfilou and the Laboratoire National de Santé Publique respectively. Proportion of malaria cases and geometric mean parasite density were higher at the CSI «Maman Mboualé» compared to over sites (P-value <0.001). However the multiplicity of infection was higher at the Hôpital de Mfilou (P-value <0.001). At the Laboratoire National de Santé Publique, malaria cases and multiplicity of infection were not influenced by different seasons. However, variation of the mean parasite density was statistically significant (P-value <0.01). Hi...Continue Reading

References

May 11, 2011·International Journal of Environmental Research and Public Health·Aklesso Egbendewe-MondzozoXiming Wu
May 23, 2012·Malaria Journal·Heidi L ReidArchie C A Clements
Sep 18, 2012·Global Journal of Health Science·L M SamdiA Ayanlade
Dec 25, 2016·Malaria Journal·Felix Koukouikila-Koussounda, Francine Ntoumi

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Methods Mentioned

BETA
PCRs
genotyping
electrophoresis

Software Mentioned

SPSS

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