Variation of Serum Lycopene in Response to 100% Watermelon Juice: An Exploratory Analysis of Genetic Variants in a Randomized Controlled Crossover Study

Current Developments in Nutrition
Kristi M Crowe-WhiteAmy C Ellis

Abstract

Watermelon, a rich source of lycopene, has garnered attention for cardioprotective effects including cholesterol reduction and promotion of redox balance. It is unknown whether 100% watermelon juice may represent a food-first approach to confer cardioprotective benefits of lycopene. This study examined influences of 100% watermelon juice on serum lycopene, lipids, and antioxidant capacity. Secondly, the study explored genetic influences on lycopene metabolism and bioavailability. A placebo-controlled, randomized, double-blind, crossover trial with postmenopausal women (n = 16, mean ± SD age: 60 ± 4.1 y) assessed effects of 100% watermelon juice on mechanistic and clinical outcomes influencing vascular function. Participants maintained low-lycopene diets for a 1-wk run-in period and throughout the study. Morning and evening consumption of 100% watermelon juice provided a daily dose of 14.4 ± 0.34 mg lycopene. Study arms of 4 wk were separated by a 2-wk washout period. Saliva was collected for genetic analysis of single nucleotide polymorphisms, and fasting blood samples were taken pre- and post-study arms. Statistical analyses included mixed models, linear regression, and nonparametric tests. Serum lycopene exhibited a significa...Continue Reading

References

Nov 1, 1989·Archives of Biochemistry and Biophysics·P Di MascioH Sies
Feb 24, 2001·Critical Reviews in Biotechnology·J Shi, M Le Maguer
Mar 7, 2002·The Journal of Nutrition·Susan Zaripheh, John W Erdman
Nov 9, 2002·Experimental Biology and Medicine·David Heber, Qing-Yi Lu
Apr 4, 2003·The Journal of Nutrition·Alison J EdwardsBeverly A Clevidence
Jul 18, 2003·Journal of Lipid Research·Veda Diwadkar-NavsariwalaPhyllis E Bowen
Jul 28, 2005·The Journal of Nutrition·Marisa Porrini, Patrizia Riso
Jul 21, 2007·The British Journal of Nutrition·Karin JacobGaspar Ros Berruezo
Dec 2, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ekaterina M PaliakovJ Alexander Bralley
Feb 12, 2009·Journal of Food Composition and Analysis : an Official Publication of the United Nations University, International Network of Food Data Systems·Lisa HarnackJohn Himes
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kin-Weng KongNor Fadilah Rajab
Jun 19, 2010·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Patrizia RisoMarisa Porrini
Mar 11, 2011·The American Journal of Clinical Nutrition·Lenore ArabAlfonso Ang
Sep 12, 2012·Annals of Nutrition & Metabolism·P PalozzaA Cittadini
Jul 13, 2013·Archives of Biochemistry and Biophysics·Nancy E MoranSteven K Clinton
Feb 13, 2015·Critical Reviews in Food Science and Nutrition·Lars MüllerVolker Böhm
Mar 17, 2015·Free Radical Biology & Medicine·Patrick BorelRomain Bott
Oct 18, 2016·Critical Reviews in Food Science and Nutrition·Kristi Crowe-WhitePaula Ziegler
Feb 11, 2016·Nutrients·Christopher R D'AdamoPatrick F McArdle
Nov 30, 2016·Journal of Nutrition in Gerontology and Geriatrics·Amy Cameron EllisKristi Crowe-White
May 22, 2018·Journal of Nutrition in Gerontology and Geriatrics·Seung Eun JungKristi Crowe-White
Jun 8, 2018·Frontiers in Pharmacology·Ioana MozosAtanas G Atanasov
Nov 27, 2018·Advances in Nutrition·Katelyn E SenkusKristi M Crowe-White
Feb 14, 2019·Plant Foods for Human Nutrition·Amy C EllisKristi Crowe-White

❮ Previous
Next ❯

Citations

Aug 5, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Amy C EllisKristi M Crowe-White
Oct 14, 2021·Journal of Nutrition in Gerontology and Geriatrics·Kristi M Crowe-WhiteAmy C Ellis

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Clinical Trials Mentioned

NCT03626168

Software Mentioned

SAS
SIMS Sensory Quality Panel Software

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.