Variation of systolic blood pressure in rats exposed to cadmium and nickel

Environmental Research
Seung-jun WangBong-suk Cha

Abstract

This research was intended to verify separate and combined effects of cadmium and nickel on blood pressure in rats. After cadmium chloride (CdCl(2)) and nickel chloride (NiCl(2)) were administered individually and combined by intraperitoneal injection to rats daily for a week, systolic blood pressure of the tails were measured at 1, 5, 10, 20, and 30 days after administration. Each substance was injected into rats with 0.1 mg/kg x bw and 1.0 mg/kg x bw concentrations. After 0.1 mg/kg x bw CdCl(2) was injected, statistically significant differences from the control group (only saline) were found at 1, 5, and 10 days. After 0.1 mg/kg x bw NiCl(2) was injected, no statistically significant differences from the control group were found. After 0.1 mg/kg x bw CdCl(2) and 0.1 mg/kg x bw NiCl(2) were injected combined simultaneously, statistically significant differences from the control group were found at 1, 5, and 10 days, compared with the 0.1 mg/kg x bw CdCl(2) group after 5 days and the 0.1 mg/kg x bw NiCl(2) group after 5 and 10 days. After 1.0 mg/kg x bw CdCl(2) was injected, statistically significant differences from the control group were found at 1, 5, 10, and 20 days. After 1.0 mg/kg x bw NiCl(2) was injected, statistically...Continue Reading

References

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Citations

Jun 23, 2006·Archives of Environmental Health·Isao KuriharaKoji Nogawa
Nov 9, 2015·Biological Trace Element Research·J SuliburskaD Barałkiewicz
Aug 27, 2005·Human & Experimental Toxicology·A Skoczynska, H Martynowicz
Jul 6, 2017·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Jacob K KresovichLifang Hou
Jun 28, 2006·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Vassilios TzotzesHaris Carageorgiou
Aug 15, 2009·Biological Trace Element Research·Zhan LiWang-Suo Wu
Nov 13, 2019·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Daniel R McKeatingAnthony V Perkins
Jan 22, 2021·Current Hypertension Reviews·Airton C MartinsMonica M B Paoliello

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