Mar 21, 2018

Variation of Traditional Biomarkers of Liver Injury After an Ultramarathon at Altitude

Sports Health
Jill N TirabassiM Khodaee


Significant elevations of traditional biomarkers of liver injury can occur as a result of running an ultramarathon. Traditional serum biomarker levels of liver injury will significantly increase as the result of participating in this 161-km race at altitude. Prospective cross-sectional study. Level 3. A total of 64 (before) and 83 (after) volunteer runners participated in a prospective observational field-based study at the Leadville 100 ultramarathon race. Changes in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatine kinase (CK), and bilirubin levels were measured. Of 669 athletes who started the race, 352 successfully completed the race within the 30-hour cutoff (53%). Of 36 runners who had pre- and postrace blood samples taken, the mean ALT, AST, and bilirubin levels were increased from 23 ± 10 U/L, 23 ± 5 U/L, and 0.60 ± 0.29 mg/dL to 117 ± 106 U/L, 485 ± 500 U/L, and 1.60 ± 0.61 mg/dL, respectively (all P < 0.001). There was no change in the mean ALP level ( P = 0.11). There were no significant correlations between postrace ALT, AST, ALP, lactate dehydrogenase (LDH), and bilirubin levels and athletes' age, sex, body mass index, or finishing time. Significant positiv...Continue Reading

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Mentioned in this Paper

Prevalence Studies
Biological Markers
Observational Study
Laboratory Studies
Macro-Creatine Kinase
Human Volunteers
Alkaline Phosphatase Measurement
Bilirubin, (4E,15E)-Isomer

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