Variation on a theme: investigating the structural repertoires used by ferric uptake regulators to control gene expression

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Sabina SarvanJean-François Couture

Abstract

In every living organism, the control of metal homoeostasis is a tightly regulated process coordinated by several intertwined biological pathways. In many bacteria, the ferric uptake regulator (Fur) family of transcriptional factors (TFs) are key factors in controlling the expression of genes involved in metal homeostasis and can also regulate the expression of genes involved in responses to oxidative stresses. Since the crystallization of Escherichia coli Fur DNA binding domain, the crystal structure of several metalloregulators have been reported. While the Fur family of proteins adopt similar structures, each contains unique structural features relating to their specific biological functions. Moreover, recent groundbreaking studies have provided additional insights into the mechanisms underlying the binding of DNA by these metalloregulators. In this review, we present a comprehensive overview of the crystal structure of Fur family metalloregulators with a specific focus on the new structures of these TFs bound to DNA.

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Citations

Dec 21, 2019·The Journal of Biological Chemistry·Karina A Baksh, Deborah B Zamble
Jul 18, 2019·Frontiers in Cellular and Infection Microbiology·Michał ŚmigaTeresa Olczak
Jul 11, 2020·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Kristel BergIngar Leiros
Jun 6, 2019·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·S NaderI Michaud-Soret
Oct 14, 2020·The Journal of Biological Chemistry·Justin M BradleyNick E Le Brun
Feb 6, 2021·Gut Microbes·Yohannes SeyoumChristèle Humblot
Feb 2, 2021·Archives of Biochemistry and Biophysics·Emma SevillaMaría F Fillat
Jan 25, 2021·The Journal of Biological Chemistry·Karina A Baksh, Deborah B Zamble
Jan 18, 2021·The Journal of Biological Chemistry·Justin M BradleyNick E Le Brun
May 10, 2020·Trends in Microbiology·Erin E Price, Jeffrey M Boyd
Aug 22, 2021·Nucleic Acids Research·Francisco Javier Marcos-TorresJulia J Griese

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Methods Mentioned

BETA
footprinting
Immunoprecipitation
electrophoretic
phosphotransferase

Software Mentioned

Ec
Sc Nur
Cj
Zur

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