PMID: 7541406May 1, 1995Paper

Variational expression of functionally different macrophage markers (27E10, 25F9, RM3/1) in normal gingiva and inflammatory periodontal disease

Journal of Clinical Periodontology
R Schlegel GómezM Simon

Abstract

Keratinocytes and macrophages share under immunologically activated conditions several surface proteins. We investigated immunohistochemically with monoclonal antibodies and the APAAP technique the expression pattern of 27E10 antigen (inflammatory macrophages), 25F9 antigen (resident macrophages) and RM3/1 antigen (intermediate macrophages in healing tissue) in 29 specimen biopsies of different stages of gingivitis and periodontitis. Macrophages of each subtype exhibited a different localization pattern depending on the stage of inflammation. Furthermore, suprabasal oral gingival epithelia showed a constant 27E10 expression, independent of the stage of inflammation. In contrast, all layers of the sulcus and pocket epithelia in gingivitis and periodontitis were strongly 27E10-positive, indicating immunological activation. 25F9 antigen was expressed on basal keratinocytes independent of the stage of inflammation, whereas RM3/1 was constantly negative on keratinocytes. The expression pattern of these functionally different macrophage markers on lesional macrophages and keratinocytes indicates varying differentiation and activation and suggests a participation of these cells in the local immune response in periodontal infection.

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Citations

Dec 18, 2002·Oral Microbiology and Immunology·E GemmellG J Seymour
May 9, 1998·Oral Microbiology and Immunology·F A RobertsS M Michalek
Apr 9, 2001·Infection and Immunity·K F Ross, M C Herzberg
Dec 14, 2002·Journal of Periodontology·Petri K NurmenniemiMatti L E Knuuttila
Mar 6, 2007·Journal of Periodontology·Swati Y RawalDimitris N Tatakis
Dec 5, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Pelin OktayogluKemal Nas
May 9, 2006·Journal of Periodontal Research· SuryonoToshihiko Nagata
Jun 28, 2005·Dental Clinics of North America·Dimitris N Tatakis, Purnima S Kumar
Dec 2, 2014·International Journal of Peptides·Mayank Hans, Veenu Madaan Hans
Nov 30, 2016·Experimental Biology and Medicine·Francesca OmettoAndrea Doria
Dec 9, 1997·Journal of Dental Research·F A RobertsS M Michalek
Apr 27, 2004·Periodontology 2000·Erica Gemmell, Gregory J Seymour
Apr 22, 1999·The Journal of Pathology·C C ChappleN Hunter
Jul 19, 2006·Photosynthesis Research·Christina Kaiblinger, Martin T Dokulil
Jul 1, 1997·The Journal of Dermatology·R S GomezP von den Driesch
Sep 1, 2000·Journal of Periodontology·Tetsuo KobayashiHiromasa Yoshie
Oct 1, 2001·Journal of Periodontology·Tetsuo KobayashiHiromasa Yoshie
May 27, 2021·FEMS Microbiology Reviews·Elleke F BosmaSolvej Siedler
Jul 1, 2021·Journal of Inflammation·Christoph SpiekermannThomas Vogl

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