PMID: 11934568Apr 6, 2002Paper

Variations among clinical isolates of Staphylococcus aureus to induce expression of E-selectin and ICAM-1 in human endothelial cells

FEMS Immunology and Medical Microbiology
J StrindhallE Kihlström

Abstract

Eighteen clinical isolates of Staphylococcus aureus, nine methicillin-sensitive and nine methicillin-resistant, were investigated for their ability to induce expression of E-selectin and ICAM-1 in human endothelial cells. Upregulation of adhesion molecules varied between isolates; 17 isolates induced expression of E-selectin and 13 of ICAM-1. Some isolates induced a significant expression of E-selectin without stimulation of ICAM-1, whereas the opposite was not found. Bacterial viability was required for induction of the adhesion molecules. The kinetics of ICAM-1 expression in S. aureus-infected cells differed from those stimulated with interleukin-1beta (IL-1beta). On the other hand, expression of E-selectin was very similar in S. aureus-infected and IL-1beta-stimulated cells. There was no correlation between ability of S. aureus to induce expression of cell adhesion molecules, methicillin susceptibility, pulse field gel electrophoresis patterns, biochemical characteristics, phage typing and toxin production.

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Citations

Aug 6, 2008·Critical Care Medicine·Christoph J HemmerEmil C Reisinger
May 27, 2003·Journal of Medical Virology·Salla SaijetsMerja Roivainen
Oct 23, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lisa StarkPer-Eric Lindgren
Apr 17, 2009·International Journal of Environmental Health Research·Stefan BorjessonPer-Eric Lindgren
Jul 30, 2004·The Journal of Antimicrobial Chemotherapy·Danuta KruszewskaAsa Ljungh

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