PMID: 7542151Jul 1, 1995Paper

Variations in activity of the human natural anti-Gal antibody in young and elderly populations

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
L WangU Galili

Abstract

Anti-Gal is a natural antibody which constitutes approximately 1% of circulating IgG in humans and which interacts specifically with the mammalian carbohydrate epitope Gal alpha 1-3Gal beta 1-4GlcNAc-R (termed the alpha-galactosyl epitope). The purpose of this study was to determine whether there are age-associated changes in the affinity of anti-Gal in elderly individuals. The age-associated variations in affinity of anti-Gal were determined by the extent of this antibody binding to solid-phase alpha-galactosyl epitopes (mouse laminin) in ELISA, performed at various serum dilutions with serum samples from 140 elderly and 127 young individuals. The data were expressed as the mean of optical density (O.D.) values measured at serum dilutions of 1:40, 1:80, and 1:160, and correlated with the affinity of anti-Gal as measured in equilibrium dialysis. The proportion of individuals with low-affinity anti-Gal is sixfold higher in the elderly than in the young population. Whereas low-affinity binding of anti-Gal (mean O.D. value < or = 1.0) was observed in only 6% of the young population, as many as 35% of the elderly population displayed such low-affinity anti-Gal. Anti-Gal affinity in ELISA assay correlated with the affinity of this a...Continue Reading

Citations

Aug 2, 2003·Journal of the American Chemical Society·Yun ZhangPeng George Wang
Dec 29, 2015·Seminars in Thoracic and Cardiovascular Surgery·Narutoshi HibinoMark Galantowicz
Dec 13, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Miguel Pérez FontánNieves Domenech
Oct 16, 2014·Tissue Engineering. Part B, Reviews·Uri Galili
Aug 13, 2011·Journal of Immunological Methods·Jens Magnus Bernth-JensenSteffen Thiel
Aug 15, 2006·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Uri Galili
May 11, 2005·Immunological Reviews·Donna M Murasko, Jiu Jiang
Mar 29, 2006·Melanoma Research·James M G LarkinColin D Porter
Mar 19, 2002·Xenotransplantation·Katsuhito TeranishiDavid K C Cooper
Mar 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kim M WigglesworthUri Galili
Apr 26, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yanxia WuYanping Wang
Mar 16, 2017·Advances in Wound Care·Uri Galili
Feb 9, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Léo BoussametLaureline Berthelot

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