Variations in actual practice patterns and their deviations from the clinical practice guidelines for nephrotic syndrome in Japan: certified nephrologists' questionnaire survey

Clinical and Experimental Nephrology
Kakuya NiihataIzaya Nakaya

Abstract

Few good-quality clinical trials on adults with nephrotic syndrome exist. Thus, there are discrepancies between real-world practice and clinical practice guidelines. We conducted a questionnaire-based survey to investigate potential discrepancies and the factors associated with variations in clinical practice. A questionnaire was administered electronically to all board-certified nephrologists in Japan. To examine clinical practice variations in relation to physician characteristics, we estimated the ratio of the mean duration of steroid therapy using a generalized linear model, and the odds ratio of higher level ordinal variables using an ordered logistic regression model. Responses of the 116 participants showed some variation for the majority of questions. Most participants (94.8%) indicated that screening for malignant tumors was "Conducted for almost all patients". The duration of steroid therapy was found to be longer among physicians seeing ≥ 30 patients with nephrotic syndrome per month, both for minimal-change disease (ratio of mean 1.69; 95% CI 1.07-2.66) and membranous nephropathy (ratio of mean 1.71; 95% CI 1.09-2.69). We identified practice patterns for nephrotic syndrome and discrepancies between clinical practice...Continue Reading

References

Mar 3, 2010·The Journal of Rheumatology·Deanna CettomaiLisa Christopher-Stine
Aug 24, 2016·The Journal of Antimicrobial Chemotherapy·Johan MaertensUNKNOWN 5th European Conference on Infections in Leukaemia (ECIL-5), a joint venture of the European Group for Blood and Marrow Tran

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Citations

Mar 10, 2020·Clinical and Experimental Nephrology·Hiroo KawarazakiTakeshi Nakata
Mar 2, 2021·The Journal of Clinical Hypertension·Hiroki NishiwakiUNKNOWN Japan Nephrotic Syndrome Cohort Study group

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