Variations in adequate levothyroxine replacement therapy in patients with different causes of hypothyroidism.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
M B Gordon, M S Gordon

Abstract

To compare the levothyroxine replacement dose in 181 patients with various causes of hypothyroidism. We analyzed the dose of levothyroxine used in the following five patient groups: (1) 37 patients with hypothyroidism after radioiodine therapy for Graves' thyrotoxicosis who were receiving a stable (for at least 4 years) replacement dose (mean time after 131 I therapy, 11.3 years); (2) 36 patients with Hashimoto's hypothyroidism (chronic autoimmune thyroiditis with a goiter or positive test results for antithyroid antibodies); (3) 36 patients with central hypothyroidism; (4) 36 patients with hypothyroidism after near-total thyroidectomy and 131 I therapy for thyroid carcinoma with negative total-body 131 I scans who were euthyroid when receiving levothyroxine; and (5) 36 patients with atrophic thyroiditis (no goiter and negative test results for antithyroid antibodies). Adequacy of levothyroxine replacement dose was defined as a normal thyrotropin level and clinical euthyroidism in patients with primary hypothyroidism and a serum free thyroxine index in the upper half of the normal range in conjunction with clinical euthyroidism in patients with central hypothyroidism. The mean (+/- standard error of the mean) replacement dosage...Continue Reading

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Citations

Jul 11, 2001·Endocrinology and Metabolism Clinics of North America·I Klein
Dec 17, 2002·Thyroid : Official Journal of the American Thyroid Association·Ilan ShimonDavid Olchovsky
Jul 15, 2011·Thyroid : Official Journal of the American Thyroid Association·Madhuri DevdharJacqueline Jonklaas
Sep 8, 2012·Thyroid : Official Journal of the American Thyroid Association·Jeffrey R GarberUNKNOWN American Association Of Clinical Endocrinologists And American Thyroid Association Taskforce On Hypothyroidism In Adults
Jun 10, 2010·International Journal of General Medicine·Rosemarie A Wright-Pascoe
Oct 1, 2014·Thyroid : Official Journal of the American Thyroid Association·Vincenzo Di DonnaSalvatore Maria Corsello
Oct 1, 2014·Thyroid : Official Journal of the American Thyroid Association·Jacqueline JonklaasUNKNOWN American Thyroid Association Task Force on Thyroid Hormone Replacement
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Mar 27, 2012·The Medical Clinics of North America·Jaime P Almandoz, Hossein Gharib
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Sep 25, 2018·The Journal of Clinical Endocrinology and Metabolism·Dorina Ylli, Leonard Wartofsky
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Oct 17, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jacqueline Jonklaas
Dec 19, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey R GarberUNKNOWN American Association of Clinical Endocrinologists and American Thyroid Association Taskforce on Hypothyroidism in Adults
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Jul 3, 2019·The Journal of Clinical Endocrinology and Metabolism·Chiara MelePaolo Marzullo
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