Variations in angiotensin-converting enzyme gene insertion/deletion polymorphism in Indian populations of different ethnic origins

Journal of Biosciences
M A Qadar PashaS K Brahmachari

Abstract

The pattern of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in the Indian population is poorly known. In order to determine the status of the polymorphism, young unrelated male army recruits were screened. The population had cultural and linguistic differences and lived in an environment that varied significantly from one region to another. Analysis of the genotype, showed higher frequency of the insertion allele in four of the five groups i.e. I allele frequency was significantly higher (P < 0.05) in Dogras, Assamese and Kumaonese. The deletion allele frequency was comparatively higher in the fifth group that belonged to Punjab. A correlation was observed between the genotype and enzyme activity. Involvement of a single D allele in the genotype enhanced the activity up to 37.56 3.13%. The results suggested ethnic heterogeneity with a significant gene cline with higher insertion allele frequency. Such population-based data on various polymorphisms can ultimately be exploited in pharmacogenomics.

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Citations

Sep 1, 2005·Human Genetics·UNKNOWN Indian Genome Variation Consortium
May 14, 2011·The Journal of Obstetrics and Gynaecology Research·Shagun AggarwalSarita Agarwal
Oct 7, 2004·Neurobiology of Aging·Robert StewartAnthony Mann
Apr 20, 2006·Diabetes Research and Clinical Practice·Puneet Pal SinghSarabjit Mastana
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Apr 29, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Yue QiDong Zhao
Mar 17, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Thouraya BaroudiAmel Benammar-Elgaaied
Sep 2, 2005·Genetica·Deepak GroverMitali Mukerji
Oct 12, 2013·Journal of Basic and Clinical Physiology and Pharmacology·Shuchi BhagiShashi Bala Singh
May 14, 2020·Archives of Physiology and Biochemistry·Babak HadianNegar Nouryazdan
Jun 29, 2016·Journal of Genetics·Shobha KumariKallur N Saraswathy

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