PMID: 2508313Jan 1, 1989Paper

Variations in arterioles in spontaneously hypertensive rats. Morphometric analysis of afferent and efferent arterioles

Virchows Archiv. A, Pathological Anatomy and Histopathology
K KimuraT Sugimoto

Abstract

In the present study, the diameters of afferent and efferent arterioles of kidneys from spontaneously hypertensive rats (SHR) were evaluated and compared with those from Wistar Kyoto rats. (WKY) using a vascular cast model. At 4 weeks of age, the blood pressure was slightly higher in SHR than in WKY (124 +/- 1 vs 116 +/- 7 mmHg, ns). The diameters of afferent arterioles in SHR were smaller than those in WKY (10.3 +/- 0.6 vs 12.3 +/- 0.7 microns, P less than 0.001), whereas the diameters of efferent arterioles were comparable in the two strains. At 20 weeks of age, the blood pressure was markedly elevated in SHR than in WKY (192 +/- 5 vs 140 +/- 4 mmHg, P less than 0.001). The diameters of afferent arterioles in SHR at this age were much smaller than those in WKY (14.3 +/- 0.5 vs 17.1 +/- 0.6 microns, P less than 0.01). The diameters of efferent arterioles in SHR were, however, larger than those in WKY (15.4 +/- 1.2 vs 12.9 +/- 0.4 microns, P less than 0.05). The net effect of these changes in arteriolar size helps to maintain normal intraglomerular pressure and to protect glomeruli from damage due to hypertension.

References

Sep 1, 1984·Japanese Heart Journal·V H GattoneA P Evan
May 1, 1984·The Journal of Clinical Investigation·L D DworkinB M Brenner
Jan 1, 1983·Hypertension·V H GattoneF C Luft
Jun 1, 1982·Pflügers Archiv : European journal of physiology·C H Hsu, J M Slavicek

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Citations

Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KimuraT Sugimoto
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·A TojoT Sugimoto
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·H Wehner, G Nelischer
Jun 11, 2011·Virchows Archiv : an International Journal of Pathology·Sabine LehBjarne M Iversen
Jun 13, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroyuki SasamuraHiroshi Itoh
Sep 1, 1996·Clinical and Experimental Pharmacology & Physiology·M M KettD Alcorn
Jul 1, 1997·Clinical and Experimental Pharmacology & Physiology·M FujimakiS Uchida
Jul 31, 2004·Acta Physiologica Scandinavica·K Skov, M J Mulvany
Mar 19, 2005·Journal of Hypertension·Amany ShwetaWarwick P Anderson
Sep 25, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mikako HisamichiYugo Shibagaki
Jan 15, 2002·American Journal of Physiology. Renal Physiology·Bernardo Rodríguez-IturbeHéctor A Pons
Oct 3, 1999·Physiological Reviews·J Zicha, J Kunes
May 23, 2018·American Journal of Hypertension·Patricia Martinez-QuinonesCamilla F Wenceslau
May 8, 1999·Journal of the American Society of Nephrology : JASN·J R Nyengaard

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