PMID: 9179923May 1, 1997Paper

Variations in expression of copper/zinc superoxide dismutase in villous trophoblast of the human placenta with gestational age

Placenta
A L WatsonGraham J Burton

Abstract

This study investigated expression of the key antioxidant enzyme copper/zinc superoxide dismutase in the villous trophoblast of the human placenta at different gestational ages from 8 weeks (last menstrual period) to term. Immunostaining for the enzyme was observed in the cytotrophoblast cells at all stages. Staining was generally absent from the syncytiotrophoblast at 8 weeks, except for small isolated areas close to the basal surface. The size and location of these areas suggested they were the result of recent cytotrophoblastic fusion. By 10 weeks, examples were more frequent and diffuse staining throughout most of the syncytiotrophoblast was observed at 12 weeks. The intensity of the immunostaining within the syncytiotrophoblast continued to increase until 14 weeks, by which time it matched generally that within the cytotrophoblast cells. A similar pattern of staining was observed within term material. These results are entirely consistent with the hypothesis that the oxygen tension within the intervillous space is low throughout the first trimester of pregnancy. They support the idea that an effective maternal circulation to the human placenta is only established at the start of the second trimester.

References

Jun 1, 1989·Journal of Molecular and Cellular Cardiology·R K LiW G Williams
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·C M Troy, M L Shelanski
Jan 1, 1993·Free Radical Biology & Medicine·C C Winterbourn
Jan 1, 1993·Free Radical Biology & Medicine·W H Koppenol
Dec 1, 1959·The Journal of Obstetrics and Gynaecology of the British Empire·J M CRAWFORD

❮ Previous
Next ❯

Citations

Sep 11, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·S QanungoM Mukherjea
Sep 10, 2003·Obstetrics and Gynecology·Jemma JohnsEric Jauniaux
May 30, 1998·Early Human Development·E JauniauxC Rodeck
Sep 29, 2001·Gynécologie, obstétrique & fertilité·G J Burton, E Jaunaiux
Nov 21, 2009·Human Reproduction Update·K G PringleC T Roberts
Jul 21, 1998·Annals of the New York Academy of Sciences·J R Woods
Aug 21, 2013·Nutrients·Jessica A GriegerVicki L Clifton
Jun 30, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Joanna L JamesLawrence W Chamley
May 13, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroSonia S Hassan
Nov 12, 2015·The Journal of Obstetrics and Gynaecology Research·Ebru BiberogluNuri Danisman
May 31, 2011·Respiratory Physiology & Neurobiology·Henning Schneider
Feb 23, 2010·Medical Hypotheses·Andrea L Tranquilli, Beatrice Landi
Feb 19, 2015·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·E LymperakiE Vagdatli
Apr 30, 2005·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E JauniauxG J Burton
Feb 15, 2005·Placenta·E Jauniaux, G J Burton
Dec 7, 2010·Best Practice & Research. Clinical Obstetrics & Gynaecology·Graham J Burton, Eric Jauniaux
May 14, 2016·Journal of Psychiatric Research·Mehmet Akif CamkurtTaha Can Tuman
Feb 1, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Mehmet Akif CamkurtMehmet Fatih Karaaslan
Sep 8, 2004·Journal of the Society for Gynecologic Investigation·Graham J Burton, Eric Jauniaux
May 2, 2015·Polish Journal of Veterinary Sciences·M SzczubiałR Urban-Chmiel
Aug 24, 2018·Biology of Reproduction·Hamid-Reza Kohan-GhadrSascha Drewlo
Jun 1, 1998·Annals of the New York Academy of Sciences·James R Woods
Jan 14, 2012·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Cleofina Bosco, Eugenia Diaz
Jul 20, 2012·American Journal of Physiology. Endocrinology and Metabolism·M CocquebertT Fournier
May 20, 1998·The Journal of Clinical Endocrinology and Metabolism·A L WatsonG J Burton
Oct 20, 2005·Human Reproduction Update·J L JamesL W Chamley
Dec 14, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Roland Abi NahedNadia Alfaidy
Oct 17, 1998·Journal of Perinatal Medicine·J Gardosi
May 6, 2003·The Journal of Nutrition·Esther Casanueva, Fernando E Viteri
Nov 28, 2018·International Journal of Molecular Sciences·Jon G StellerApril E Ronca
Nov 7, 2017·Birth Defects Research·Helen E RitchieJaimie W Polson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.