Abstract
To characterize the contour and duration of aortic flow-velocity waveforms in the normal human, the ascending aorta of 23 persons without evidence of cardiovascular disease was examined systematically with pulsed Doppler echocardiography. In 16 of the 23 subjects, measurements throughout the ascending aorta showed flow-velocity waveforms of similar contour and duration, characterized by flow-velocity peaking in early to midsystole, with most flow velocity (60 +/- 4%) occurring in the first half of the available systolic ejection period, and then gradually decreasing to 0 baseline coincident with aortic valve closure. In the other 7 subjects, aortic flow-velocity waveforms recorded at most of the sampling sites also revealed a normal flow-velocity pattern; however, in each of these subjects, 1 to 3 sites that displayed a distinct alteration from the normal pattern were also identified. The waveforms recorded from these latter sites were characterized by flow-velocity peaking earlier in systole and decelerating to 0 baseline approximately 100 ms before aortic valve closure; consequently, a particularly large fraction of flow velocity (88 +/- 9%) occurred in the first half of the systolic ejection period. These apparently shortene...Continue Reading
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