PMID: 18712091Aug 21, 2008Paper

Variations in glycoprotein IIb-IIIa (alphaIIb/beta3-integrin) content in healthy donors. Influence on platelet aggregation activity and efficacy of aspirin action

Biomedit︠s︡inskai︠a︡ khimii︠a︡
S G KhaspekovaA V Mazurov

Abstract

Effects of fibrinogen receptor, glycoprotein (GP) IIb-IIIa (alphaII/(beta3-integrin) content, GP IIIa genetic polymorphism (substitution Leu33Pro) and fibrinogen concentration in blood plasma on platelet aggregation activity were studied in a group of healthy volunteers. The GP IIb-IIIa content on platelet surface in 35 tested donors varied (40-71) x 10(3) per platelet. Repeated measurements revealed that the GP IIb-IIIa content coefficient of variation was 9.5%, and deviations from mean levels did not exceed 20%. The level and rate of platelet aggregation induced by ADP (1.25-20 M) correlated with GP IIb-IIIa number (r from 0.315 to 0.591) and were higher in a group of donors with high in comparison with low GP IIb-IIIa content (> 60 and (40-50) x 10(3) per platelet respectively). Aspirin, the inhibitor of thromboxane A2 synthesis, partially suppressed ADP-induced platelet aggregation. The level of residual aggregation in the presence of aspirin also correlated with GP IIb-IIIa content and increased in subjects with high receptor content. Parameters of ADP-induced aggregation did not differ in donors with GP IIIa Pro33(-) (Leu33Leu33, n = 20) and Pro33(+) (Leu33Pro33, n = 13, and Pro33Pro33, n = 2) genotype. GP IIb-IIIa conten...Continue Reading

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