Variations in inflammatory genes as molecular markers for prediction of inflammatory bowel disease occurrence

Journal of Digestive Diseases
Biljana StankovicSonja Pavlovic

Abstract

Research on inflammatory bowel disease (IBD) has highlighted genes involved in the regulation of inflammatory responses as contributors to disease pathogenesis. This study aimed to evaluate the associations between IBD and variations in NOD2, TLR4, TNF-α, IL-6, IL-1β and IL-1RN genes, and to use the genetic data obtained in predictive modeling. A total of 167 IBD patients and 101 healthy controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism. Using the genotype data attained as the input to various classification algorithms, IBD prediction models were designed. The area under the receiver operating characteristic curve (AUROC) was used to measure their performance. Significant associations were found between Crohn's disease (CD) and minor NOD2 variants, as well as TLR4 299Gly, TNF-α G-308A, IL-6 G-174C and IL-1RN VNTR A2 variants, while ulcerative colitis (UC) was associated only with IL-1RN VNTR A2 variants. CD and UC showed highly significant difference in the allelic distribution of TNF-α G-308A, where the A allele was found to be related to CD, and the G allele to UC. A combined effect of patients' gender and TLR4 variants was observed among CD patients. When all analyzed genotype and ...Continue Reading

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Citations

Apr 30, 2017·European Journal of Gastroenterology & Hepatology·Sanja DragasevicDragan Popovic
Nov 13, 2018·Journal of Immunology Research·Maria DobreMircea Mănuc
Oct 14, 2020·International Journal of Colorectal Disease·Beatriz Piantoni GonçalvesAndréa Name Colado Simão
May 21, 2021·Clinical Genetics·Joana CouceiroAlexandre Quintas

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