Variations in internal structure, composition and protein distribution between intra- and extra-articular knee ligaments and tendons

Journal of Anatomy
Yalda A KharazEithne J Comerford

Abstract

Tendons and ligaments play key roles in the musculoskeletal system in both man and animals. Both tissues can undergo traumatic injury, age-related degeneration and chronic disease, causing discomfort, pain and increased susceptibility to wider degenerative joint disease. To date, tendon and ligament ultrastructural biology is relatively under-studied in healthy, non-diseased tissues. This information is essential to understand the pathology of these tissues with regard to function-related injury and to assist with the future development of tissue-engineered tendon and ligament structures. This study investigated the morphological, compositional and extracellular matrix protein distribution differences between tendons and ligaments around the non-diseased canine stifle joint. The morphological, structural characteristics of different regions of the periarticular tendons and ligaments (the intra-articular anterior cruciate ligament, the extra-articular medial collateral ligament, the positional long digital extensor tendon and energy-storing superficial digital flexor tendons) were identified using a novel semi-objective histological scoring analysis and by determining their biochemical composition. Protein distribution of extrac...Continue Reading

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Citations

Feb 23, 2020·Nature Reviews. Rheumatology·Eric GraceyDirk Elewaut
Apr 16, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jeffrey Ryan HillSpencer P Lake
Feb 14, 2021·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Othman J AliThomas W Maddox
Apr 23, 2021·PloS One·Tomoko HiguchiHideto Watanabe
Jul 17, 2021·Scandinavian Journal of Medicine & Science in Sports·Yalda A KharazEithne Comerford

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Methods Mentioned

BETA
laser capture microdissection

Software Mentioned

GraphPad Prism
SPSS Statistics
Adobe photoshop
Adobe photoshop CS

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