PMID: 7546494Jul 1, 1995Paper

Variations in magnesium and zinc in hypertensive patients receiving different treatments

American Journal of Hypertension
M A Rubio-LuengoJ D Luna del Castillo

Abstract

We studied the influence of captopril, atenolol, and verapamil on serum and intraerythrocyte concentrations of magnesium and zinc in 30 normotensive control subjects (12 men and 18 women, aged 30 to 65 years, mean +/- SD 45.76 +/- 12.15 years) and 30 patients with untreated mild or moderate essential hypertension (14 men and 16 women, aged 30 to 65 years, mean +/- SD 49.50 +/- 13.58 years). Ten each of the hypertensive patients were treated with captopril, atenolol, or verapamil. Physical examination and biochemical analyses (serum Mg and Zn) were done in all participants at baseline, and in patients after 3 and 6 months of treatment. The results were compared according to a nested design with Neumann-Keuls test. We found no significant differences between controls and patients in serum and intraerythrocyte concentrations of Zn at the start of the study, although there was a significant decrease in serum Zn in patients after 3 (P < .01) and 6 months (P < .001) of treatment, regardless of the drug used. This decrease was thought to be attributable to the zincuric effect of captopril or to dietary measures, or both. Intraerythrocyte Zn was not significantly affected by antihypertensive treatment. Serum and intraerythrocyte concen...Continue Reading

Citations

Jul 5, 2006·Heart Failure Reviews·Syamal K BhattacharyaKarl T Weber
Jul 2, 1998·Scandinavian Journal of Gastroenterology·T H NaberJ B Jansen
Jan 3, 2013·International Journal of Clinical Practice·L A Braun, F Rosenfeldt
Jul 5, 2006·Heart Failure Reviews·Natan Cohen, Ahuva Golik
Jan 15, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Rhian M Touyz
Nov 26, 2020·BMJ Nutrition, Prevention & Health·J P Mossink
Jun 24, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Satish Kumar Taneja, Reshu Mandal

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