Variations in postprandial ghrelin status following ingestion of high-carbohydrate, high-fat, and high-protein meals in males

Annals of Nutrition & Metabolism
Dalia Tannous dit El KhouryNahla Hwalla

Abstract

The purpose of this study was to investigate the response of postprandial acylated ghrelin to changes in macronutrient composition of meals in healthy adult males. A randomized crossover study was performed. Ten healthy adult males were recruited. All subjects received, on separate occasions, a high-carbohydrate (HC), a high-fat (HF), and a high-protein (HP) meal. Blood samples were collected before and 15, 30, 60, 120, and 180 min following the ingestion of each meal. Plasma acylated ghrelin as well as serum insulin, glucose, and triglycerides were measured. The levels of acylated ghrelin fell significantly following the three meals. The HC meal induced the most significant decrease in postprandial ghrelin secretion (-15.5 +/- 2.53 pg/ml) as compared with HF (-8.4 +/- 2.17 pg/ml) and HP (-10.0 +/- 1.79 pg/ml) meals (p < 0.05). However, at 180 min, the HP meal maintained significantly lower mean ghrelin levels (29.7 +/- 3.56 pg/ml) than both HC (58.4 +/- 5.75 pg/ml) and HF (45.7 +/- 5.89 pg/ml) meals and lower levels than baseline (43.4 +/- 5.34 pg/ml) (p <0.01). The postprandial insulin levels increased to significantly higher levels following the HC meal (+80.6 +/- 11.14 microU/ml) than following both HF (37.3 +/- 4.82 microU...Continue Reading

References

Oct 30, 1998·The Proceedings of the Nutrition Society·R J Stubbs
Oct 27, 2001·Diabetes·A M WrenS R Bloom
Jan 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Daniel E FlanaganRobert S Sherwin
Jan 30, 2003·Journal of Endocrinological Investigation·M MöhligA F H Pfeiffer
Mar 18, 2003·Endocrinology·Koji ToshinaiMasamitsu Nakazato
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·David S WeigleJonathan Q Purnell
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Jara NedvídkováKarel Pacak
Nov 6, 2003·Regulatory Peptides·Johannes ErdmannVolker Schusdziarra
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Palmiero MonteleoneMario Maj
Feb 10, 2004·The Journal of Endocrinology·R B HeathM D Robertson
Mar 11, 2004·Clinical Endocrinology·Yona GreenmanNaftali Stern
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Johannes ErdmannVolker Schusdziarra
Aug 13, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K L WhitedH E Raybould
Aug 25, 2004·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·N TentolourisN Katsilambros
Sep 24, 2004·The British Journal of Nutrition·Daniel Tome
Oct 20, 2004·Regulatory Peptides·Frida LeonettiUmberto Di Mario
Nov 4, 2004·The Journal of Clinical Endocrinology and Metabolism·C W le RouxS R Bloom

❮ Previous
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Citations

Apr 7, 2012·Endocrine·Amy C EllisBarbara A Gower
Sep 30, 2010·The British Journal of Nutrition·Nerys M AstburyIan A Macdonald
Jul 8, 2011·The British Journal of Nutrition·Brittany M Vester BolerGeorge C Fahey
May 30, 2007·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S M TiekenW W Campbell
Feb 4, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Geórgia Franco BeckerAlvaro Reischak-Oliveira
Aug 2, 2007·Annual Review of Nutrition·Frédéric TremblayAndré Marette
Jan 2, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jenny TongPatrick Tso
Dec 17, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Todd A HagobianBarry Braun
Aug 28, 2010·International Journal of Peptides·Chrysi KoliakiNicholas Katsilambros
Jan 17, 2008·The Journal of Clinical Endocrinology and Metabolism·Karen E Foster-SchubertDavid E Cummings
Oct 13, 2009·The Journal of Clinical Endocrinology and Metabolism·Jefferson P LomenickJames W Anderson
Apr 11, 2014·International Journal of Endocrinology and Metabolism·Marzyeh SaghebjooSaeed Ilbeigi
Aug 9, 2011·Journal of Nutrition and Metabolism·Neil A SchwarzRodney G Bowden
Oct 22, 2010·Nutrition Reviews·Paul A M SmeetsCees de Graaf
Mar 6, 2012·Regulatory Peptides·Amy C EllisBarbara A Gower
Jan 5, 2010·Metabolism: Clinical and Experimental·Abbass Ghanbari-NiakiRobert R Kraemer
Jan 20, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Flavia ProdamGianni Bona
May 12, 2012·Animal Science Journal = Nihon Chikusan Gakkaihō·Brittany M VesterKelly S Swanson
Dec 12, 2013·Molecular Metabolism·Maja S EngelstoftThue W Schwartz
Mar 10, 2015·Journal of the American College of Nutrition·Ann G LiuNikhil V Dhurandhar
Nov 29, 2011·Regulatory Peptides·Florian LipplVolker Schusdziarra
Mar 8, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Lauren M BeckmanCarrie P Earthman
Jun 22, 2019·Toxicology Mechanisms and Methods·Nibedita Nayak, Monalisa Mishra
Dec 30, 2009·Pharmacological Reviews·Chih-Yen ChenAkio Inui
Mar 10, 2007·Journal of Applied Physiology·D R BroomM Miyashita

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